Metabolic activation of diethylstilbestrol: Indirect evidence for the formation of a stilbene oxide intermediate in hamster and rat
Metabolic activation of diethylstilbestrol: Indirect evidence for the formation of a stilbene oxide intermediate in hamster and rat
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己烯雌酚的代谢激活：仓鼠和大鼠中氧化二苯乙烯中间体形成的间接证据
DOI：
10.1016/0006-2952(75)90373-1
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发表时间：
1975
影响因子：
5.8
通讯作者：
M. Metzler
中科院分区：
文献类型：
--
作者：
M. Metzler
代谢产物GLC a）含量中的M+ c）尿潴留质量B）时间谱”仓鼠大鼠A DES 12.4/14.6 412/417 4.7 ndd）B羟基-DES 16.7/18。O 500/505 nd 6.0 C甲氧基-DES 15.2/17.9 442/447 nd D二甲氧基-DES 18.8/20.9 472/477 nd E二烯雌酚18.8 410/414 0.8 2.7 F羟基-二烯雌酚22.4 498/502 3.2 0.5 G甲氧基-二烯雌酚21.4 440/444 nd用双（ON）-三甲基甲硅烷基乙酰胺进行三甲基甲硅烷基化后的代谢物1.3a5;玻璃柱6 ft. x 1/4”，2 mm内径，3% 0 V-22-在GasC-rom Q 100/120目上，He 30 ml/min，温度程序160- 26 ℃，4 ℃/min。在芪中发现的两个峰对应于顺式和反式异构体。B）分子离子M+是指TMS-衍生物;双信号是由于用作ai：i混合物的氘代和非氘代DES。c）5天内排泄的剂量%;由于仅使用少数动物，因此该值为半定量值。A5未检测到。
Metabolite GLC a) M+ in Content c) in urine retention mass b) time spectrum" hamster rat A DES 12.4/14.6 412/417 4.7 ndd) B hydroxy-DES 16.7/18. O 500/505 nd 6.0 C methoxy-DES 15.2/17.9 442/447 nd nd D dimethoxy-DES 18.8/20.9 472/477 nd nd E dienestrol 18.8 410/414 0.8 2.7 F hydroxy-dienestrol 22.4 498/502 3.2 0.5 G methoxy-dienestrol 21.4 440/444 nd 1.3 a5 of metabolites after trimethylsilylation with bis (ON)-trimethylsilylacetamide; glass column 6 ft. x 1/4", 2 mm id, 3% 0V-22~ on GasC~ rom Q 1OO/120 mesh, He 30 ml/min., temperature program 160-26OvC with 4 C/min. The two peaks found with stilbenes correspond to the cis-and transisomer. b) the molecular ions M+ refer to the TMS-derivatives; the twin signals are due to the deuterated and non-deuterated DES employed as ai: i mixture. c)% of dose excreted within 5 days; the values are semiquantitative since only a few animals were used. a5 not detected.