Fluorodeoxyglucose positron emission tomography in leiomyosarcoma: imaging characteristics.
Fluorodeoxyglucose positron emission tomography in leiomyosarcoma: imaging characteristics.
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DOI：
10.1097/mnm.0b013e32832bcaec
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发表时间：
2009-07
影响因子：
1.5
通讯作者：
Conrad EU
中科院分区：
文献类型：
--
作者：
Punt SE;Eary JF;O'Sullivan J;Conrad EU
平滑肌肉瘤是一种平滑肌恶性肿瘤，占肉瘤的7%。平滑肌肉瘤患者的平均生存期为5年。这些肿瘤来源于间充质组织，很难诊断，治疗方案也存在争议。这种软组织肉瘤亚型相对罕见的发病率限制了可用于研究和研究的患者数量。本研究探讨了正电子发射断层扫描（PET）与放射性标记氟脱氧葡萄糖（FDG）的成像特征是否提供了一种可靠的、无创的方法来预测平滑肌肉瘤患者的肿瘤行为。在新辅助化疗或切除前对参与研究的患者肿瘤进行18F-FDG PET检查，计算最大肿瘤标准摄取值（SUVmax）。SUVmax与肿瘤分级（P=0.001）和肿瘤大小（Pλ=λ0.004）相关。这些数据的分析表明FDG PET成像在预测肿瘤分级方面的潜在有效性。在平滑肌肉瘤中，FDG PET的SUVmax可能是肿瘤行为的预测因子。使用FDG PET成像数据改善平滑肌肉瘤的临床治疗可能会增加患者的生存率。
Leiomyosarcoma, a malignant neoplasm of smooth muscle, accounts for 7% of the sarcomas. Patients with leiomyosarcoma tumors have an average survival of 5 years. These tumors, which are derived from mesenchymal tissues, are difficult to diagnose and treatment options remain controversial. The relatively rare incidence of this soft tissue sarcoma subtype has limited the number of patients available for studies and research. This study examines whether the imaging characteristics of positron emission tomography (PET) with radiolabeled fluorodeoxyglucose (FDG) provide a reliable, noninvasive means to predict tumor behavior in patients with leiomyosarcomas. 18F-FDG PET was performed on the tumors of participating patients before the neoadjuvant chemotherapy or resection, and a maximum tumor standard uptake value (SUVmax) was calculated. The SUVmax was correlated with tumor grade (P=0.001) and tumor size as greatest dimension (Pλ=λ0.004). Analysis of this data indicated the potential effectiveness of FDG PET imaging in predicting tumor grade. In leiomyosarcoma, the SUVmax from FDG PET is a likely predictor of tumor behavior. Improvements made in the clinical treatment of leiomyosarcomas by use of FDG PET imaging data may lead to an increase in patient survival.