′′One‐Pot′′ Selective Synthesis of 3,4‐Disubstituted Pyrroles and Benzo[f]indole‐4,9‐diones from 1,3‐Indanedione, Aromatic Aldehydes and TosMIC
′′One‐Pot′′ Selective Synthesis of 3,4‐Disubstituted Pyrroles and Benzo[f]indole‐4,9‐diones from 1,3‐Indanedione, Aromatic Aldehydes and TosMIC
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DOI：
10.1002/slct.201700997
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发表时间：
2017-08
期刊：
影响因子：
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通讯作者：
Anjaiah Aitha;Nagaraju Payili;Santhosh Reddy Rekula;Satyanarayana Yennam;J. Anireddy
中科院分区：
文献类型：
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作者：
Anjaiah Aitha;Nagaraju Payili;Santhosh Reddy Rekula;Satyanarayana Yennam;J. Anireddy
以易得的芳香醛、1，3-茚二酮和对甲苯磺酰基甲基异腈（TosMIC）为原料，采用一锅法高收率地合成了多种3，4-二取代吡咯和苯并[f]吲哚-4，9-二酮。该方法具有操作简单、底物范围广、试剂使用方便等特点。一锅顺序反应建议通过串联原位生成的查尔酮和[3+2]-环加成/环断裂或扩展过程进行。
A variety of 3,4‐disubstituted pyrroles and benzo[f]indole‐4,9‐diones have been selectively synthesized from readily available aromatic aldehydes, 1,3‐Indanedione and tosylmethyl isocyanide (TosMIC) by a one‐pot procedure in high yields. This methodology features operationally simple, practical with broad substrate scope and usage of easy to handle reagents. The one‐pot sequential reactions proposed to proceeds through a tandemin situgenerated chalcones and [3+2]‐cycloaddition/ring cleavage or expansion process.