FORMIN a link between kinetochores and microtubule ends.
FORMIN a link between kinetochores and microtubule ends.
复制标题
形成动粒和微管末端之间的联系。
DOI：
10.1016/j.tcb.2011.08.005
复制
发表时间：
2011
影响因子：
19
通讯作者：
Mao,Yinghui
中科院分区：
文献类型：
--
作者：
Mao,Yinghui
哺乳动物肌动蛋白相关（mDia）双胍蛋白因其在肌动蛋白动力学中具有肌动蛋白成核和丝伸长活性而闻名。它们还直接与微管结合，并在细胞迁移过程中调节细胞边缘的微管稳定。最近，formin mDia3被证明与着丝点相关，并有助于中期染色体排列，在这个过程中，着丝点与生长和收缩的微管形成稳定的附着。我们认为formin mDia3可以通过其自身的微管结合活性以及与末端结合蛋白EB1（末端结合蛋白1）的相互作用来协调附着，从而促进着丝蛋白结合微管动力学的调节。
The mammalian diaphanous-related (mDia) formin proteins are well known for their actin-nucleation and filament-elongation activities in mediating actin dynamics. They also directly bind to microtubules and regulate microtubule stabilization at the leading edge of the cell during cell migration. Recently, the formin mDia3 was shown to associate with the kinetochore and to contribute to metaphase chromosome alignment, a process in which kinetochores form stable attachments with growing and shrinking microtubules. We suggest that the formin mDia3 could contribute to the regulation of kinetochore-bound microtubule dynamics, in coordination with attachment via its own microtubule-binding activity, as well as via its interaction with the tip-tracker EB1 (end-binding protein 1).