First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques
First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques
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DOI：
10.1038/s41575-019-0167-1
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发表时间：
2019-09-01
影响因子：
65.1
通讯作者：
Tack, Jan
中科院分区：
文献类型：
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作者：
Corsetti, Maura;Costa, Marcello;Tack, Jan
结肠动力的改变与肠道疾病的病理生理学有关，但高分辨率的人体结肠运动功能测压显示，我们对正常运动模式的了解是有限的。此外，已经使用各种术语和定义来描述儿童、成人和动物的结肠运动模式。一个例子是人类的高振幅传播收缩和动物的巨大收缩之间的区别。需要统一的术语和定义，适用于基础科学家和临床医生以及成人和儿科胃肠病学家进行的结肠动力研究。由于临床研究越来越需要足够的动物模型来开发和测试新的疗法，因此需要合理使用术语来描述动物和人类之间等效的运动模式。本共识声明首次统一解释了描述结肠运动功能的常用术语，并描述了在动物模型和人体体外（离体）和体内观察到的运动模式之间可能的相似性。统一的术语可以推动新的研究，这将大大提高我们对结肠运动功能的理解，并将促进结肠动力障碍新疗法的开发和测试。
Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminologies and definitions have been used to describe colonic motor patterns in children, adults and animals. An example is the distinction between the high-amplitude propagating contractions in humans and giant contractions in animals. Harmonized terminology and definitions are required that are applicable to the study of colonic motility performed by basic scientists and clinicians, as well as adult and paediatric gastroenterologists. As clinical studies increasingly require adequate animal models to develop and test new therapies, there is a need for rational use of terminology to describe those motor patterns that are equivalent between animals and humans. This Consensus Statement provides the first harmonized interpretation of commonly used terminology to describe colonic motor function and delineates possible similarities between motor patterns observed in animal models and humans in vitro (ex vivo) and in vivo. The consolidated terminology can be an impetus for new research that will considerably improve our understanding of colonic motor function and will facilitate the development and testing of new therapies for colonic motility disorders.