A review of the health effects of green tea catechins in in vivo animal models
A review of the health effects of green tea catechins in in vivo animal models
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DOI：
10.1093/jn/134.12.3431s
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发表时间：
2004-12-01
影响因子：
4.2
通讯作者：
Williamson, G
中科院分区：
文献类型：
--
作者：
Crespy, V;Williamson, G
体外研究有充分证据表明绿茶儿茶素在预防退行性疾病方面具有作用。然而，体外研究中使用的浓度往往高于在动物或人体血浆中发现的浓度，因此需要体内证据来证明儿茶素的任何保护作用。本文总结了关于绿茶儿茶素对癌症、心血管疾病和其他退行性疾病的生物标志物的保护作用的最有趣的体内动物研究。一般来说，大多数使用动物模型的研究表明，饮用绿茶（儿茶素）具有一定的保护作用，尽管大多数研究没有检测剂量反应。茶儿茶素可作为抗肿瘤剂和免疫调节剂，用于移植肿瘤或致癌物处理引起的免疫功能障碍。绿茶对肝癌细胞有抗增殖活性，对肝癌处理的大鼠有降血脂活性，一些研究报告称它可预防肝毒性。它可作为乳腺癌启动后的预防剂。然而，绿茶儿茶素在预防转移方面的作用尚未明确确立。长期喂食茶儿茶素可能通过调节脂质代谢有益于抑制高脂肪饮食诱导的肥胖，可能对与2型糖尿病有关的脂质和葡萄糖代谢紊乱有有益影响，还可能降低冠心病的风险。需要进一步研究其作用机制、活性化合物的性质以及适当的剂量水平。
There is good evidence from in vitro studies that green tea catechins have a role in protection against degenerative diseases. However, the concentrations used in vitro are often higher than those found in animal or human plasma, and so in vivo evidence is required to demonstrate any protective effect of catechins. This article summarizes the most interesting in vivo animal studies on the protective effects of green tea catechins against biomarkers for cancer, cardiovascular disease, and other degenerative diseases. Generally, most studies using animal models show that consumption of green tea (catechins) provides some protection, although most studies have not examined dose response. Tea catechins could act as antitumorigenic agents and as immune modulators in immunodysfunction caused by transplanted tumors or by carcinogen treatment. Green tea has antiproliferative activity in hepatoma cells and hypolipidemic activity in hepatoma-treated rats, and some studies report that it prevents hepatoxicity. It could act as a preventive agent against mammary cancer postinitiation. Nevertheless, the implications of green tea catechins in preventing metastasis have not been clearly established. Long-term feeding of tea catechins could be beneficial for the suppression of high-fat diet-induced obesity by modulating lipid metabolism, could have a beneficial effect against lipid and glucose metabolism disorders implicated in type 2 diabetes, and could also reduce the risk of coronary disease. Further investigations on mechanisms, the nature of the active compounds, and appropriate dose levels are needed.