The Evolutionary Relationship between Alternative Splicing and Gene Duplication.
The Evolutionary Relationship between Alternative Splicing and Gene Duplication.
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DOI：
10.3389/fgene.2017.00014
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发表时间：
2017
影响因子：
3.7
通讯作者：
Hernández G
中科院分区：
文献类型：
--
作者：
Iñiguez LP;Hernández G
今天存在的蛋白质多样性是各种进化过程的结果。众所周知，基因复制（GD）以及突变的积累是导致不同蛋白质数量增加的原因之一。真核生物的基因结构需要去除非编码序列、内含子，才能产生成熟的 mRNA。该过程称为顺式剪接，此处称为剪接，受多种因素调节，这些因素可导致多种剪接排列，通常称为选择性剪接（AS）。 AS 在单个基因中产生多种转录亚型，也增加了蛋白质的多样性。然而，AS 和 GD 之间蛋白质变异增加的进化和方式有所不同。一个重要的问题是 GD 事件后 AS 模式如何受到影响。在这里，我们回顾一下目前对AS和GD的认识，重点关注它们的进化关系。这两个过程现在被认为是蛋白质多样性增加的主要贡献者，因此它们的关系是进化研究的一个相关但尚未得到充分研究的领域。
The protein diversity that exists today has resulted from various evolutionary processes. It is well known that gene duplication (GD) along with the accumulation of mutations are responsible, among other factors, for an increase in the number of different proteins. The gene structure in eukaryotes requires the removal of non-coding sequences, introns, to produce mature mRNAs. This process, known as cis-splicing, referred to here as splicing, is regulated by several factors which can lead to numerous splicing arrangements, commonly designated as alternative splicing (AS). AS, producing several transcripts isoforms form a single gene, also increases the protein diversity. However, the evolution and manner for increasing protein variation differs between AS and GD. An important question is how are patterns of AS affected after a GD event. Here, we review the current knowledge of AS and GD, focusing on their evolutionary relationship. These two processes are now considered the main contributors to the increasing protein diversity and therefore their relationship is a relevant, yet understudied, area of evolutionary study.