Effects of Reduced Kidney Function Because of Living Kidney Donation on Left Ventricular Mass
Effects of Reduced Kidney Function Because of Living Kidney Donation on Left Ventricular Mass
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DOI：
10.1161/hypertensionaha.116.08175
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发表时间：
2017-02-01
期刊：
影响因子：
8.3
通讯作者：
Buchner, Stefan
中科院分区：
文献类型：
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作者：
Altmann, Ursula;Boeger, Carsten A.;Buchner, Stefan
活体肾脏捐赠与心血管死亡率的小幅但显著增加相关。此外，轻度肾功能下降与慢性肾病患者的左心室质量增加和心血管疾病相关。为了研究这种关联，我们评估了活体肾脏捐献后肾功能轻度下降对亚临床心脏结构和功能变化的影响。在这项前瞻性队列研究中，对23名活体肾脏供体（平均年龄54 ± 10岁，52%为男性）在捐赠前和肾切除术后4个月和12个月进行了心脏和肾脏磁共振成像和实验室分析。平均估计肾小球滤过率在捐献前为102 +/- 15 mL min-1 1.73 m-2，在12个月时为70 +/- 13 mL min-1 1.73 m-2（P
Living kidney donation is associated with a small but significant increase in cardiovascular mortality. In addition, mildly decreased kidney function is associated with an increase of left ventricular mass and with cardiovascular disease in patients with chronic kidney disease. To investigate this association, we evaluated the impact of mildly decreased kidney function after living kidney donation on subclinical cardiac structural and functional changes. In this prospective cohort study, cardiac and renal magnetic resonance imaging and laboratory analyses were performed in 23 living kidney donors (mean age 54 +/- 10 years, 52% male) before donation and at 4 and 12 months after nephrectomy. Mean estimated glomerular filtration rate was 102 +/- 15 mL min(-1) 1.73 m(-2) before donation and 70 +/- 13 mL min-1 1.73 m(-2) at 12 months (P