Sodium pentobarbital effects on cardiac function and response to dobutamine.
Sodium pentobarbital effects on cardiac function and response to dobutamine.
复制标题
戊巴比妥钠对心脏功能和多巴酚丁胺反应的影响。
DOI：
10.1097/00005344-198603000-00024
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发表时间：
1986
影响因子：
3
通讯作者：
Rendig,SV
中科院分区：
文献类型：
--
作者：
Segel,LD;Rendig,SV
本研究旨在确定戊巴比妥钠是否对离体工作大鼠心脏功能有持续影响，从而改变心脏对随后给予多巴酚丁胺的反应。采用戊巴比妥麻醉或颈椎骨折死亡大鼠离体工作心脏，研究戊巴比妥钠的体外治疗效果。0.4 mM戊巴比妥钠显著抑制离体心脏的血流动力学和收缩功能。将戊巴比妥从制剂中洗出后，除- dP/dt max仍下降7%外，心功能的所有指标均完全恢复。随后心脏对5× 10−8 M多巴酚丁胺的肌力反应受先前暴露于戊巴比妥的体外影响最小。数据证实，颈椎骨折死亡大鼠的心脏对多巴酚丁胺的收缩性反应比戊巴比妥麻醉大鼠的心脏要小。此外，与非通气动物相比，从通气动物切除的心脏左心室收缩压峰值、主动脉流量峰值和功率峰值明显更高，这表明在心脏切除过程中对动物进行通气以获得最佳的离体心脏功能的重要性。
This study was undertaken to determine if sodium pentobarbital had persistent effects on isolated working rat heart function that altered the response of the heart to subsequently administered dobutamine. The effects of in vitro sodium pentobarbital treatment were studied using isolated working hearts from rats that were killed after pentobarbital anesthesia or by cervical fracture. Hemodynamic and contractile functions of the isolated hearts were significantly depressed in the presence of 0.4 mM sodium pentobarbital in vitro. After the pentobarbital was washed out of the preparation, all indices of cardiac function recovered fully except for− dP/dt max, which remained depressed by 7%. The subsequent inotropic response of the hearts to 5× 10− 8 M dobutamine was minimally affected by the prior exposure to pentobarbital in vitro. The data confirmed that hearts from rats killed by cervical fracture exhibited a smaller inotropic response to dobutamine than hearts from pentobarbital-anesthetized rats. In addition, hearts excised from ventilated animals had significantly higher left ventricular peak systolic pressure, peak aortic flow rate, and peak power than hearts from nonventilated animals, indicating the importance of ventilating the animal during cardiac excision in order to obtain optimum isolated heart function.