Dysregulated RET signaling in thyroid cancer
Dysregulated RET signaling in thyroid cancer
复制标题
DOI：
10.1016/j.ecl.2008.02.006
复制
发表时间：
2008-06-01
影响因子：
4.5
通讯作者：
Santoro, Massimo
中科院分区：
文献类型：
--
作者：
Castellone, Maria Domenica;Santoro, Massimo
许多生物过程和癌症等疾病都依赖于酪氨酸激酶受体的激活。二十年前，RET酪氨酸激酶受体作为一种转化基因被发现，随后与乳头状甲状腺癌和髓样甲状腺癌的形成有关。本文对RET癌蛋白激活下游信号转导通路的机制进行了研究。总而言之，这些发现促进了对甲状腺癌形成的潜在过程的理解。
Numerous biologic processes and such diseases as cancer depend on activation of tyrosine kinase receptors. The RET tyrosine kinase receptor was discovered two decades ago as a transforming gene and was subsequently implicated in the formation of papillary and medullary thyroid carcinoma. This article examines the data about the mechanism of activation of downstream signal transduction pathways by RET oncoproteins. Collectively, these findings have advanced the understanding of the processes underlying thyroid carcinoma formation.