Catalytic, Enantioselective Addition of Alkyl Radicals to Alkenes via Visible-Light-Activated Photoredox Catalysis with a Chiral Rhodium Complex
Catalytic, Enantioselective Addition of Alkyl Radicals to Alkenes via Visible-Light-Activated Photoredox Catalysis with a Chiral Rhodium Complex
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DOI：
10.1021/jacs.6b03399
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发表时间：
2016-06-08
影响因子：
15
通讯作者：
Meggers, Eric
中科院分区：
文献类型：
--
作者：
Huo, Haohua;Harms, Klaus;Meggers, Eric
在光氧化还原条件下，一种双环金属化铑催化剂（4摩尔%）可催化由有机三氟硼酸盐氧化产生的烷基自由基对受体取代的烯烃进行高效的对映选择性加成反应。这种实用的方法产率可达97%，对映选择性优异，对映体过量值可达99%，可归类为氧化还原中性的电子转移催化反应。
An efficient enantioselective addition of alkyl radicals, oxidatively generated from organotrifluor-oborates, to acceptor-substituted alkenes is catalyzed by a bis-cyclometalated rhodium catalyst (4 mol %) under photoredox conditions. The practical method provides yields up to 97% with excellent enantioselectivities up to 99% ee and can be classified as a redox neutral, electron transfer-catalyzed reaction.