Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders.
Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders.
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DOI：
10.3389/fncel.2023.1084769
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发表时间：
2023
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
神经变性与细胞骨架动力学缺陷和囊泡运输和分选系统功能障碍有关。在过去的几十年里，研究表明，细胞骨架动力学的关键调节因子是Rho家族的GTP酶，而Rab家族的GTP酶则是囊泡在靶膜之间分选和转运的中心枢纽。在这方面，Rho和Rab GTP酶在诱导和维持不同功能和形态的神经元结构域（如树突和轴突）中的作用已被广泛研究。属于这两个蛋白质家族的几个成员与从痴呆到运动神经元变性的许多神经退行性疾病相关。在这项分析中，我们试图提出一个简短的审查之间的潜在串扰的Rab和Rho家族成员在神经退行性疾病，如阿尔茨海默氏病（AD），帕金森氏病（PD），亨廷顿病，和肌萎缩侧索硬化症（ALS）。
Neurodegeneration is associated with defects in cytoskeletal dynamics and dysfunctions of the vesicular trafficking and sorting systems. In the last few decades, studies have demonstrated that the key regulators of cytoskeletal dynamics are proteins from the Rho family GTPases, meanwhile, the central hub for vesicle sorting and transport between target membranes is the Rab family of GTPases. In this regard, the role of Rho and Rab GTPases in the induction and maintenance of distinct functional and morphological neuronal domains (such as dendrites and axons) has been extensively studied. Several members belonging to these two families of proteins have been associated with many neurodegenerative disorders ranging from dementia to motor neuron degeneration. In this analysis, we attempt to present a brief review of the potential crosstalk between the Rab and Rho family members in neurodegenerative pathologies such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington disease, and amyotrophic lateral sclerosis (ALS).
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影响因子：
7.1
作者：
Borin M;Saraceno C;Catania M;Lorenzetto E;Pontelli V;Paterlini A;Fostinelli S;Avesani A;Di Fede G;Zanusso G;Benussi L;Binetti G;Zorzan S;Ghidoni R;Buffelli M;Bolognin S
通讯作者：
Bolognin S
影响因子：
4
作者：
Elfrink, Hyung Lim;Zwart, Rob;Scheper, Wiep
通讯作者：
Scheper, Wiep
影响因子：
5.1
作者：
Chandran, Jayanth;Ding, Jinhui;Cai, Huaibin
通讯作者：
Cai, Huaibin
影响因子：
5.7
作者：
Burrinha, Tatiana;Almeida, Claudia Guimas
通讯作者：
Almeida, Claudia Guimas
影响因子：
56.9
作者：
Carroll, KS;Hanna, J;Pfeffer, SR
通讯作者：
Pfeffer, SR