Quality of life in advanced oropharyngeal carcinoma after chemoradiation versus surgery and radiation
Quality of life in advanced oropharyngeal carcinoma after chemoradiation versus surgery and radiation
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DOI：
10.1097/01.mlg.0000233244.18901.44
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发表时间：
2006-09-01
期刊：
影响因子：
2.6
通讯作者：
Wang, Marilene B.
中科院分区：
文献类型：
--
作者：
Mowry, Sarah E.;Ho, Allen;Wang, Marilene B.
目的：这项来自高等学术大学实践的队列研究的目的是确定晚期口咽癌放化疗或手术和放疗后患者感知生活质量的差异。研究方法：从机构数据库中，确定了35例接受原发性放化疗或原发性手术和术后放疗的晚期口咽癌（II-IV期）患者。患者自愿使用华盛顿大学生活质量量表第4版（UW-QOL）通过邮件回复。使用卡方检验和Wilcogon检验分析数据。结果：17例患者接受了放化疗，18例患者接受了手术和术后放疗。所有手术患者均行游离皮瓣重建。患者在治疗后平均25个月完成UW-QOL。两组在任何特定领域（包括疼痛、外观、吞咽、咀嚼、言语、唾液或情绪）方面均无统计学显著差异。有一个趋势，以显着的味觉（P = 0.07）与放化疗患者报告较差的味觉功能。考虑到治疗方式的巨大差异，患者对外观和吞咽的感知没有差异是相当令人惊讶的。在回答全球生活质量问题时，受访者报告的总体生活质量相当。结论：大多数晚期口咽癌患者报告治疗后的生活质量良好，无论治疗方式。虽然治疗的短期副作用在两组之间可能不同，但无论患者选择原发性放化疗还是手术加术后放疗，长期生活质量都非常相似。
Objective: The objective of this cohort study from a tertiary academic university practice was to identify differences in patients' perceived quality of life after either chemoradiation or surgery and radiation for advanced-stage oropharyngeal carcinoma. Methods: From institutional databases, thirty-five patients were identified who had undergone either primary chemoradiation or primary surgery and postoperative radiation for advanced oropharyngeal cancer (stage II-IV). Patients voluntarily responded by mail using the University of Washington quality-of-life instrument version 4 (UW-QOL). Data were analyzed using chi(2) and Wilcogon tests. Results: There were 17 patients who underwent chemoradiation and 18 patients who underwent surgery and postoperative radiation. All surgical patients had undergone free-flap reconstruction. Patients completed the UW-QOL an average of 25 months after treatment. There was no statistically significant difference between the two groups with regard to any specific domain, including pain, appearance, swallowing, chewing, speech, saliva, or mood. There was a trend toward significance for taste (P =.07) with chemoradiation patients reporting poorer taste function. The lack of difference in the patients' perception of appearance and swallowing was rather surprising given the vastly different treatment modalities. Respondents reported equivalent overall quality of life in response to global quality-of-life questions. Conclusion: Most patients with advanced oropharyngeal carcinoma report good quality of life after treatment, regardless of treatment modality. Although the short-term side effects of treatment may be different between the groups, long-term quality of life is remarkably similar whether the patients choose primary chemoradiation or surgery with postoperative radiation.