Calcium signaling in taste cells: regulation required.
Calcium signaling in taste cells: regulation required.
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DOI：
10.1093/chemse/bjq082
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发表时间：
2010-11
期刊：
影响因子：
3.5
通讯作者：
K. Medler
中科院分区：
文献类型：
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作者：
K. Medler
外周味觉受体细胞依赖于不同的钙信号来产生适当的细胞反应，将味觉信息传递给中枢神经系统。一些味觉细胞具有传统的化学突触，并依赖于通过电压门控钙通道的钙内流。其他味觉细胞缺乏这些突触，依赖于从储存中释放的钙通过半通道形成输出信号。尽管钙信号在味觉细胞中很重要，但人们对这些信号是如何调节的知之甚少。本文综述了近年来在味觉细胞中发现的2种钙清除机制，包括线粒体钙摄取和钠/钙交换体（NCX）。这些研究确定了一种独特的组成性钙内流，有助于维持味觉细胞中适当的钙稳态，以及线粒体和交换剂在此过程中的作用。NCXs在诱发钙反应的调节中的额外作用也进行了讨论。很明显，钙信号在味觉细胞中是一个动态过程，并且似乎比以前认识到的更复杂。
Peripheral taste receptor cells depend on distinct calcium signals to generate appropriate cellular responses that relay taste information to the central nervous system. Some taste cells have conventional chemical synapses and rely on calcium influx through voltage-gated calcium channels. Other taste cells lack these synapses and depend on calcium release from stores to formulate an output signal through a hemichannel. Despite the importance of calcium signaling in taste cells, little is known about how these signals are regulated. This review summarizes recent studies that have identified 2 calcium clearance mechanisms expressed in taste cells, including mitochondrial calcium uptake and sodium/calcium exchangers (NCXs). These studies identified a unique constitutive calcium influx that contributes to maintaining appropriate calcium homeostasis in taste cells and the role of the mitochondria and exchangers in this process. The additional role of NCXs in the regulation of evoked calcium responses is also discussed. Clearly, calcium signaling is a dynamic process in taste cells and appears to be more complex than has previously been appreciated.