A multiscale model of thrombus development.
A multiscale model of thrombus development.
复制标题
血栓形成的多尺度模型。
DOI：
10.1098/rsif.2007.1202
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Alber,Mark
中科院分区：
文献类型：
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作者：
Xu,Zhiliang;Chen,Nan;Kamocka,MalgorzataM;Rosen,ElliotD;Alber,Mark
介绍了一种用于研究血管中血栓（凝块）形成的二维多尺度模型。它涉及用于建模粘性不可压缩血浆的组件;非活化和活化血小板;血细胞;活化化学品;纤维蛋白原;和血管壁及其相互作用。血液流动的宏观动力学由连续Navier-Stokes方程描述。用扩展的随机离散细胞Potts模型描述了活化血小板、血小板与纤维蛋白原以及血小板与血管壁之间的微尺度相互作用。该模型的鲁棒性进行了测试，相对于基本参数的波动。模拟结果表明，血栓的内部结构不均匀的发展，这是由初步的实验数据证实。我们还对血栓发展的不同阶段进行了预测，这些预测可以通过实验进行测试，并建议进行特定的实验。最后，我们证明了在模拟中血栓大小对血液流速的依赖性接近于实验观察到的。
A two-dimensional multiscale model is introduced for studying formation of a thrombus (clot) in a blood vessel. It involves components for modelling viscous, incompressible blood plasma; non-activated and activated platelets; blood cells; activating chemicals; fibrinogen; and vessel walls and their interactions. The macroscale dynamics of the blood flow is described by the continuum Navier–Stokes equations. The microscale interactions between the activated platelets, the platelets and fibrinogen and the platelets and vessel wall are described through an extended stochastic discrete cellular Potts model. The model is tested for robustness with respect to fluctuations of basic parameters. Simulation results demonstrate the development of an inhomogeneous internal structure of the thrombus, which is confirmed by the preliminary experimental data. We also make predictions about different stages in thrombus development, which can be tested experimentally and suggest specific experiments. Lastly, we demonstrate that the dependence of the thrombus size on the blood flow rate in simulations is close to the one observed experimentally.