Detection of tissue remodelling by Fast Field-Cycling methods

Detection of tissue remodelling by Fast Field-Cycling methods
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通过快速场循环方法检测组织重塑

DOI:
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发表时间:
2015
期刊:
影响因子:
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通讯作者:
D. Lurie
D. Lurie
中科院分区:
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文献类型:
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作者:
L. Broche;V. Zampetoulas;P. Ross;D. Lurie

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快速场循环(FFC)通过允许在一定场强范围内(通常在20 uT和0.2 T之间)测量T1,扩展了MRI的潜力。这是一项丰富的技术,能够将物理化学性质与聚合物,多孔介质或液晶中的应用结合起来,举几个例子(1)我们的研究小组旨在将FFC转化为MRI(2)并开发了创新的FFC-MRI扫描仪,其中两个是目前正在运行的全身扫描仪。在这里,我们描述了我们的发现,从6年的实验与临床相关的试点研究,使用FFC-MRI和FFC-NMR对各种人体组织。
Fast Field-Cycling (FFC) extends the potential of MRI by allowing measurement of T1 over a range of field strengths, typically between 20 uT and 0.2 T. It is a rich technique that is able to characterise physico-chemical properties with applications in polymers, porous media or liquid crystals, to cite a few (1) Our research group aims to translate FFC to MRI (2) and has developed innovative FFC-MRI scanners, two of which are whole-body scanners currently in operation. Here we describe our findings from 6 years of experimentation with clinically-relevant pilot studies using FFC-MRI and FFC-NMR on various human tissues.