Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort
Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort
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DOI：
10.1017/s0007114518000417
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发表时间：
2018-05-28
影响因子：
3.6
通讯作者：
Tucker, Katherine L.
中科院分区：
文献类型：
--
作者：
DeChristopher, Luanne R.;Tucker, Katherine L.
越来越多的证据表明，摄入高果糖玉米糖浆（HFCS），HFCS-sweetened soda，水果饮料和苹果汁（一种高果糖100%的果汁）与哮喘有关，可能是因为高果糖：葡萄糖比例和潜在的果糖吸收不良，这可能有助于肠道形成促炎性晚期糖基化终末产物，其结合受体是哮喘的介质。使用来自弗雷明汉后代队列的数据，使用考克斯比例风险模型来评估这些饮料的摄入量与哮喘风险之间的关联。饮食苏打水和橙子汁-一种100%的果汁，果糖：葡萄糖比例为1：1-被包括在内进行比较。增加HFCS加糖苏打水、水果饮料和苹果汁的任何组合的摄入量与进行性更高的哮喘风险显著相关，在5-7次/周与从不/很少的情况下达到稳定，与潜在的混杂因素无关（危害比1.91，P
There is growing evidence that intakes of high-fructose corn syrup (HFCS), HFCS-sweetened soda, fruit drinks and apple juice - a high-fructose 100% juice - are associated with asthma, possibly because of the high fructose:glucose ratios and underlying fructose malabsorption, which may contribute to enteral formation of pro-inflammatory advanced glycation end products, which bind receptors that are mediators of asthma. Cox proportional hazards models were used to assess associations between intakes of these beverages and asthma risk, with data from the Framingham Offspring Cohort. Diet soda and orange juice - a 100% juice with a 1:1 fructose:glucose ratio - were included for comparison. Increasing intake of any combination of HFCS-sweetened soda, fruit drinks and apple juice was significantly associated with progressively higher asthma risk, plateauing at 5-7 times/week v. never/seldom, independent of potential confounders (hazard ratio 1.91, P