Control of translation in the cold: implications for therapeutic hypothermia.
Control of translation in the cold: implications for therapeutic hypothermia.
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DOI：
10.1042/bst20150052
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发表时间：
2015-06
影响因子：
3.9
通讯作者：
J. Knight;A. Willis
中科院分区：
文献类型：
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作者：
J. Knight;A. Willis
自20世纪50年代以来，受控全身冷却一直用于保护大脑免受脑血流量减少的损伤。治疗性低温已成功地用于心脏手术，心脏骤停后，并在其他情况下，减少血液流向大脑的各种成功。然而，为什么降低温度是有益的在很大程度上是未知的。在这里，我们回顾了治疗性低温的使用，以期了解导致这种现象的潜在生物学。有趣的是，冷却的好处最近已经扩展到两个小鼠模型中慢性神经退行性疾病的治疗。同时，研究已经证明了调节蛋白质合成、翻译对冷却反应的重要性，这也是神经变性中的一个靶向过程。通过这些研究，冷却后复温过程的潜在重要性也开始显现。总之，这些研究为操纵冷却通路以获得治疗效果提供了新的机会。
Controlled whole-body cooling has been used since the 1950s to protect the brain from injury where cerebral blood flow is reduced. Therapeutic hypothermia has been used successfully during heart surgery, following cardiac arrest and with varied success in other instances of reduced blood flow to the brain. However, why reduced temperature is beneficial is largely unknown. Here we review the use of therapeutic hypothermia with a view to understanding the underlying biology contributing to the phenomenon. Interestingly, the benefits of cooling have recently been extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies the potential importance of the rewarming process following cooling is also beginning to emerge. Altogether, these lines of research present new opportunities to manipulate cooling pathways for therapeutic gain.