FeCl2-Catalyzed selective C-C bond formation by oxidative activation of a benzylic C-H bond
FeCl2-Catalyzed selective C-C bond formation by oxidative activation of a benzylic C-H bond
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FeCl2-通过氧化活化苄基 C-H 键选择性形成 C-C 键
DOI：
10.1002/anie.200701782
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发表时间：
2007-01-01
影响因子：
16.6
通讯作者：
Li, Chao-Jun
中科院分区：
文献类型：
--
作者：
Li, Zhiping;Cao, Lin;Li, Chao-Jun
在过去的十年里，C±H键的选择性和高效功能化引起了学术界和工业界的广泛关注[1]，各种方法，特别是基于过渡金属催化剂的方法，已经被开发出来并应用于合成复杂分子。从含有苄基C±H键的原料合成苄基衍生物是众所周知的(方案1，路径A和B)，尽管多步合成仍然常用。或者，最近已经开发了各种催化方法，允许苄基C±H键的直接官能化(方案1，路径C)。[3，4]尽管过渡金属催化剂在有机合成中被广泛使用，但使用更容易获得和无毒的催化剂来代替昂贵和敏感的催化剂是非常可取的。铁的许多优点使其作为化学合成的催化剂或试剂极具吸引力。[5]在这样的体系中，铁催化的C？H键氧化
The selective and efficient functionalization of CÀH bonds has attracted much attention from both academia and industry in the past decade,[1] and various methods, especially ones based on transition-metal catalysts, have been developed and applied in the synthesis of complex molecules.[1, 2] Although great progress has been made in this area, new processes for the construction of CÀC bonds starting from CÀH bonds are still highly desirable. The synthesis of benzylic derivatives from starting materials containing a benzylic CÀH bond is well known (Scheme1, pathsA and B), although multistep syntheses are still commonly used. Alternatively, various catalytic methods have been developed recently that allow the direct functionalization of benzylic CÀH bonds (Scheme 1, path C).[3, 4]Although transition-metal catalysts are widely used in organic synthesis, the use of more readily available and nontoxic catalysts instead of expensive and sensitive catalysts is highly desirable. The numerous advantages of iron make it highly attractive as a catalyst or reagent for chemical synthesis.[5] Iron-catalyzed CÀH bond oxidations in systems such