Crossmodal propagation of sensory-evoked and spontaneous activity in the rat neocortex.
Crossmodal propagation of sensory-evoked and spontaneous activity in the rat neocortex.
复制标题
大鼠新皮质中感觉诱发和自发活动的跨模式传播。
DOI：
10.1016/j.neulet.2007.11.069
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发表时间：
2008
影响因子：
2.5
通讯作者：
Lippert,MichaelThomas
中科院分区：
文献类型：
--
作者：
Takagaki,Kentaroh;Zhang,Chuan;Wu,Jian-Young;Lippert,MichaelThomas
In the cortex, neural responses to crossmodal stimulation are seen both in higher association areas and in primary sensory areas, and are thought to play a role in integration of crossmodal sensations. We used voltage-sensitive dye imaging (VSDI) to study the spatiotemporal characteristics of such crossmodal neural activity. We imaged three cortical regions in rat: primary visual cortex (V1), barrel field of primary somatosensory cortex (S1bf) and parietal association area (PA, flanked by V1 and S1bf). We find that sensory-evoked population activity can propagate in the form of a distinct propagating wave, robustly in either crossmodal direction. In single trials, the waveforms changed continuously during propagation, with dynamic variability from trial to trial, which we interpret as evidence for cortical involvement in the spreading process. To further characterize the functional anatomy of PA, we also studied the propagation of spontaneous sleep-like waves in this area. Using a novel flow-detection algorithm, we detected a propagation bias within PA of spontaneous waves—these tend to propagate parallel to the crossmodal axis, rather than orthogonal to it. Taken together, these findings demonstrate that intracortical networks show pre-attentive crossmodal propagation of activity, and suggest a potential mechanism for the establishment of crossmodal integration.
