Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat.
Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat.
复制标题
酱油（日本酱油）对大鼠胃粘膜的长期影响。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
J. Dueck
中科院分区：
文献类型：
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作者：
W. Macdonald;J. Dueck
在完整大鼠和胃底切除术大鼠中评估酱油（日本酱料）对胃粘膜的长期影响。将100只雌性4月龄Wistar大鼠分为4组：正常和手术大鼠对照饮食和正常和手术大鼠相同的饮食饱和酱油。给予酱油的动物比对照组小; 15只接受酱料的完整大鼠在33个月时健康，而对照组只有7只。50只手术大鼠中只有9只存活33个月。对照组的10只大鼠出现了乳腺肿瘤，而给予酱油的大鼠一只也没有出现。其他肿瘤的分布也相同。两种恶性肿瘤似乎起源于手术大鼠的胃周组织：在酱油组的网状细胞肉瘤和对照组的淋巴肉瘤。未累及胃粘膜。大多数接受手术的大鼠（有或没有shoyu）都出现了小的良性胃肿瘤。在22只完整大鼠中，Shoyu的粘液组织学保存良好：15只正常，7只胃小凹细胞中有粘液丢失和核变化; 7只中有2只轻度胃炎。一个完整的对照显示片状粘液损失。在老鼠身上，酱油似乎不是致癌物;长期使用酱油既不会损害健康，也不会损害寿命。长期使用与少数大鼠的胃粘液丢失和细胞核变化有关，偶尔会出现轻度胃炎。
The long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa was assessed in intact rats and in those with a fundusectomy. One hundred female 4-month-old Wistar rats were divided into 4 groups:intact and operated rats on a control diet and intact and operated rats on the same diet saturated with shoyu. The animals given shoyu were smaller than the controls; 15 intact rats receiving the sauce were healthy at 33 months compared with 7 controls. Only 9 of 50 operated rats lived 33 months. Breast tumors developed in 10 control rats but in none given shoyu. The distribution of other tumors was the same. Two malignant neoplasms appeared to originate in the perigastric tissues of operated rats: a reticulum cell sarcoma in the shoyu group and a lymphosarcoma in the control group. None involved the gastric mucosa. Most of the operated rats (with or without shoyu) developed small benign gastric tumors. Mucosal histology was well preserved in 22 intact rats on shoyu: In 15 it was normal, in 7 there was mucus loss and nuclear changes in the cells of the gastric pits; 2 of the 7 had mild gastritis. One intact control showed patchy mucus loss. Shoyu did not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity. Long-term use was associated with gastric mucus loss and nuclear changes in a few rats, occasionally with a mild gastritis.