Fatty acid oxidation: An emerging facet of metabolic transformation in cancer.
Fatty acid oxidation: An emerging facet of metabolic transformation in cancer.
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DOI：
10.1016/j.canlet.2018.08.006
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发表时间：
2018-10-28
期刊：
影响因子：
9.7
通讯作者：
Fang X
中科院分区：
文献类型：
--
作者：
Ma Y;Temkin SM;Hawkridge AM;Guo C;Wang W;Wang XY;Fang X
癌细胞经历代谢重编程，如增强的有氧糖酵解，三羧酸循环酶的突变，以及从头合成脂肪和谷氨酰胺分解的上调。这些改变对于在不利的肿瘤微环境或转移部位的癌细胞恶性表型的发展和维持至关重要。虽然线粒体脂肪酸β氧化是一种主要的生物能量来源，但它尚未被普遍认为是癌症代谢图景的一部分。然而，在过去的几年里，人们对粮农组织途径的癌症相关性的看法发生了戏剧性的变化。最近的许多研究都提供了重要的证据支持癌症的“脂解表型”。粮农组织和其他与癌症相关的明确的代谢途径一样，在各种人类恶性肿瘤中也存在调控失调现象。癌细胞的增殖、存活、干细胞分化、耐药性和转移进展都依赖于粮农组织。粮农组织还在癌症相关免疫细胞和其他宿主细胞中重新编程，这可能有助于免疫抑制和促进肿瘤的微环境。本文回顾并阐述了我们目前对粮农组织在肿瘤发生中的多方面作用以及粮农组织途径提供的抗癌治疗机会的理解。
Cancer cells undergo metabolic reprogramming such as enhanced aerobic glycolysis, mutations in the tricarboxylic acid cycle enzymes, and upregulation of de novo lipid synthesis and glutaminolysis. These alterations are pivotal to the development and maintenance of the malignant phenotype of cancer cells in unfavorable tumor microenvironment or metastatic sites. Although mitochondrial fatty acid β-oxidation (FAO) is a primary bioenergetic source, it has not been generally recognized as part of the metabolic landscape of cancer. The last few years, however, have seen a dramatic change in the view of cancer relevance of the FAO pathway. Many recent studies have provided significant evidence to support a “lipolytic phenotype” of cancer. FAO, like other well-defined metabolic pathways involved in cancer, is dysregulated in diverse human malignancies. Cancer cells rely on FAO for proliferation, survival, stemness, drug resistance, and metastatic progression. FAO is also reprogrammed in cancer-associated immune and other host cells, which may contribute to immune suppression and tumor-promoting microenvironment. This article reviews and puts into context our current understanding of multi-faceted roles of FAO in oncogenesis as well as anti-cancer therapeutic opportunities posed by the FAO pathway.
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影响因子：
64.5
作者：
Cubillos-Ruiz JR;Silberman PC;Rutkowski MR;Chopra S;Perales-Puchalt A;Song M;Zhang S;Bettigole SE;Gupta D;Holcomb K;Ellenson LH;Caputo T;Lee AH;Conejo-Garcia JR;Glimcher LH
通讯作者：
Glimcher LH
影响因子：
29
作者：
Corbet, Cyril;Pinto, Adan;Feron, Olivier
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Feron, Olivier
影响因子：
15.9
作者：
Carracedo, Arkaitz;Weiss, Dror;Pandolfi, Pier P.
通讯作者：
Pandolfi, Pier P.
影响因子：
8
作者：
Buzzai, M;Bauer, DE;Thompson, CB
通讯作者：
Thompson, CB
Nanog通过氧化磷酸化和脂肪酸代谢的肿瘤性变化来代谢重新编程肿瘤发射类样细胞。
影响因子：
29
作者：
Chen CL;Uthaya Kumar DB;Punj V;Xu J;Sher L;Tahara SM;Hess S;Machida K
通讯作者：
Machida K