Development and validation of a treatment planning system for small animal radiotherapy: SmART-Plan
Development and validation of a treatment planning system for small animal radiotherapy: SmART-Plan
复制标题
DOI：
10.1016/j.radonc.2013.10.003
复制
发表时间：
2013-12-01
影响因子：
5.7
通讯作者：
Verhaegen, Frank
中科院分区：
文献类型：
--
作者：
van Hoof, Stefan J.;Granton, Patrick V.;Verhaegen, Frank
背景和目的：用于临床前放射治疗研究的小动物精确辐照的图像引导设备最近已经问世。为了使缩小规模的放射治疗研究，可以转化为人类的放射治疗知识，治疗计划系统的临床前studys.Material和方法：一个专门的治疗计划系统（SmART计划）的小动物放射治疗研究的开发。它是基于粒子在动物体内传输的蒙特卡罗模拟。体素几何结构源自机载锥束CT成像面板。SmART计划进行了验证，使用辐射变色膜（RCF）剂量测定在各种phanteries：均匀，multislab和一个现实的塑化鼠标geometrics.Results：SmART计划的剂量计算和RCF剂量测量在所有phanteries之间获得良好的协议。对于各种输送计划，大多数靶向剂量区域的一致性在10%以内，半影区域附近和最小1 mm准直器的差异较大，在10%和20%之间。绝对深度和横向剂量分布显示出更好的协议为5和15毫米准直器比1毫米准直器，表明准确的剂量预测最小的字段sizes.Conclusion：SmART计划提供了一个有用的剂量计算工具，临床前小动物照射研究。(C)2013作者由Elsevier爱尔兰有限公司出版。保留所有权利。
Background and purpose: Image-guided equipment for precision irradiation of small animals for pre-clinical radiotherapy research became recently available. To enable downscaled radiotherapy studies that can be translated into human radiotherapy knowledge, a treatment planning system for pre-clinical studies is required.Material and methods: A dedicated treatment planning system (SmART-Plan) for small animal radiotherapy studies was developed. It is based on Monte Carlo simulation of particle transport in an animal. The voxel geometry is derived from the onboard cone beam CT imaging panel. SmART-Plan was validated using radiochromic film (RCF) dosimetry in various phantoms: uniform, multislab and a realistic plasticized mouse geometry.Results: Good agreement was obtained between SmART-Plan dose calculations and RCF dose measurements in all phantoms. For various delivered plans agreement was obtained within 10% for the majority of the targeted dose region, with larger differences between 10% and 20% near the penumbra regions and for the smallest 1 mm collimator. Absolute depth and lateral dose distributions showed better agreement for 5 and 15-mm collimators than for a 1-mm collimator, indicating that accurate dose prediction for the smallest field sizes is difficult.Conclusion: SmART-Plan offers a useful dose calculation tool for pre-clinical small animal irradiation studies. (C) 2013 The Authors. Published by Elsevier Ireland Ltd. All rights reserved.