Loss of smell in patients with COVID-19 MRI data reveal a transient edema of the olfactory clefts
Loss of smell in patients with COVID-19 MRI data reveal a transient edema of the olfactory clefts
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DOI：
10.1212/wnl.0000000000010806
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发表时间：
2020-12-08
期刊：
影响因子：
9.9
通讯作者：
Hautefort, Charlotte
中科院分区：
文献类型：
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作者：
Eliezer, Michael;Hamel, Anne-Laurel;Hautefort, Charlotte
目的探讨2019年冠状病毒病（COVID-19）患者嗅觉功能丧失（OFL）的病理生理学机制。20例严重急性呼吸综合征冠状病毒2型（SARS-CoV 2）感染的OFL患者被纳入研究，并与20例年龄匹配的健康对照组进行比较。所有感染的患者进行嗅觉功能评估和3 T MRI，进行在疾病的早期阶段，并在1个月follow-up.ResultsAt早期阶段，SARS-CoV 2感染的患者有一个平均嗅觉评分为2.8 +/- 2.7（范围0-8），和MRI显示一个完全阻塞的OC在19 20例。对照组的嗅觉评分正常，MRI显示OC无阻塞。在1个月随访时，患者的嗅觉评分改善至8.3 +/- 1.9（范围4-10），20例患者中仅7例仍有OC阻塞。嗅觉评分与OC阻塞之间存在相关性（p = 0.004）。结论SARS-CoV 2感染患者的OFL与OC的可逆性阻塞相关。
ObjectiveTo assess the physiopathology of olfactory function loss (OFL) in patients with coronavirus disease 2019 (COVID-19), we evaluated the olfactory clefts (OC) on MRI during the early stage of the disease and 1 month later.MethodsThis was a prospective, monocentric, case-controlled study. Twenty severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-infected patients with OFL were included and compared to 20 age-matched healthy controls. All infected patients underwent olfactory function assessment and 3T MRI, performed both at the early stage of the disease and at the 1-month follow-up.ResultsAt the early stage, SARS-CoV2-infected patients had a mean olfactory score of 2.8 +/- 2.7 (range 0-8), and MRI displayed a complete obstruction of the OC in 19 of 20 patients. Controls had normal olfactory scores and no obstruction of the OC on MRI. At the 1 month follow-up, the olfactory score had improved to 8.3 +/- 1.9 (range 4-10) in patients, and only 7 of 20 patients still had an obstruction of the OC. There was a correlation between olfactory score and obstruction of the OC (p = 0.004).ConclusionOFL in SARS-CoV2-infected patients is associated with a reversible obstruction of the OC.