A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats
A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats
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DOI：
10.1037/0735-7044.118.6.1317
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发表时间：
2004-12-01
影响因子：
1.9
通讯作者：
Hull, EM
中科院分区：
文献类型：
--
作者：
Lagoda, G;Muschamp, JW;Hull, EM
内侧视前区的多巴胺(MPOA)促进雄性大鼠的交配，一氧化氮(NO)调节基础和女性刺激的MPOA多巴胺的释放。MPOA内微量注射L-硝基精氨酸甲酯(L，一种NO合成抑制剂)可阻断幼年大鼠的交配，并损害有性行为经验的雄性大鼠的交配。在其他幼鼠中，在每天暴露于笼子上方的一只接受能力的雌性大鼠7次之前，向MPOA内微量注射L或生理盐水。在第8天的无药测试中，L名字处理的大鼠的交配与未暴露的对照组相似，并且相对于生理盐水处理的雄性大鼠来说受到了损害。因此，MPOA中的NO在雄性大鼠交配和刺激敏化过程中起重要作用。
Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation in sexually experienced males. In other naive rats, L-NAME or saline was microinjected into the MPOA before each of 7 daily exposures to a receptive female placed over their cage. In a drug-free test on Day 8, copulation by L-NAME-treated rats was similar to that of unexposed controls and was impaired relative to saline-treated males. Therefore, NO in the MPOA is important for copulation and stimulus sensitization in male rats.