Vasopressin release during sepsis and septic shock in baboons and dogs.
Vasopressin release during sepsis and septic shock in baboons and dogs.
复制标题
狒狒和狗败血症和败血性休克期间加压素的释放。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
B. Benjamin
中科院分区：
文献类型：
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作者：
M. Wilson;D. Brackett;L. Hinshaw;P. Tompkins;L. Archer;B. Benjamin
用放射免疫法测定了轻度麻醉的狒狒和狗在实验性大肠杆菌感染性休克前和休克过程中的血浆加压素浓度。由于抗利尿激素是一种有效的血管收缩剂、凝血因子激活剂和心肌抑制剂，我们假设，如果在血浆中发现大量的抗利尿激素，可能与脓毒性休克综合征的生理病理有关。在狒狒和狗的血浆中都发现了相当高的抗利尿激素浓度。在狒狒中，血浆加压素浓度升高，而平均动脉血压仍在正常范围内，并且在感染性休克期间保持升高长达12小时。这种程度的血浆加压素浓度以前仅在直接下丘脑刺激或继发出血的低血压休克后报道过。
Plasma vasopressin concentration was measured by radioimmunoassay in lightly anesthetized baboons and dogs before and during experimental Escherichia coli septic shock. Since vasopressin is a potent vasoconstrictor, and activator of clotting factors and a myocardial depressant, we postulated that, if found in substantial amounts in the plasma, vasopressin may contribute to the physiopathology of the septic shock syndrome. Quite high plasma vasopressin concentrations were found in both baboons and dogs. In the baboons, increased plasma vasopressin concentrations occurred, while mean arterial blood pressure was still within normal limits and remained elevated for as long as 12 hours during septic shock. Plasma vasopressin concentrations of this magnitude have been previously reported only with direct hypothalamic stimulation or after hypotensive shock secondary to hemorrhage.