Structure determination of small molecule compounds by an electron diffractometer for 3D ED/MicroED
Structure determination of small molecule compounds by an electron diffractometer for 3D ED/MicroED
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DOI：
10.1039/d1ce01172c
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发表时间：
2021-11-19
期刊：
影响因子：
3.1
通讯作者：
Meyer, Mathias
中科院分区：
文献类型：
--
作者：
Ito, Sho;White, Fraser J.;Meyer, Mathias
3D电子衍射（3D艾德）/微电子衍射（Micro艾德）通过能够从亚微米微晶确定三维分子结构而扩展了晶体学的极限。然而，使用当前最先进的电子显微镜进行3D艾德/微艾德测量需要电子显微镜和晶体学方面的专家，这使得该方法对于仅仅需要结构的研究人员来说相当困难。在这里，我们提出了一个衍射仪专门设计的三维艾德/微艾德，并显示它是如何确定晶体结构。新研制的电子衍射仪将为许多研究人员提供一条测定小于1 μ m晶体结构的简便途径。
3D electron diffraction (3D ED)/Micro electron diffraction (MicroED) has extended the limits of crystallography by enabling the determination of three dimensional molecular structures from sub-mu m microcrystals. However, 3D ED/microED measurements using current state-of-the-art electron microscopes require experts in both electron microscopy and crystallography making the method rather difficult for researchers who simply need structures. Here, we present a diffractometer specifically designed for 3D ED/microED and show how it works for determining crystal structures. The newly developed electron diffractometer will provide many researchers with an easy path to structure determination of crystals that are less than 1 mu m in size.