Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis
Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis
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DOI：
10.1016/j.clim.2016.05.010
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发表时间：
2016-08-01
影响因子：
8.6
通讯作者：
Yachie, Akihiro
中科院分区：
文献类型：
--
作者：
Inoue, Natsumi;Shimizu, Masaki;Yachie, Akihiro
为了比较成人斯蒂尔病 (AOSD) 患者与系统性幼年特发性关节炎 (s-JIA) 患者的促炎细胞因子谱和动力学，我们分析了 33 名 AOSD 患者和 77 名 s-JIA 患者的血清细胞因子浓度，并将其与临床特征进行比较。 AOSD 和 s-JIA 患者具有共同的细胞因子谱模式，即 IL-18 显着增加。根据血清 IL-6 和 IL-18 水平将 AOSD 患者分为两个亚组。 IL-6 占主导地位的亚组中关节炎患者的数量明显较多。与 s-JIA 和 AOSD 相关的细胞因子模式具有共同特征，例如 IL-18 显着且显着增加。基于 IL-6 和 IL-18 的不同细胞因子谱可能导致不同的临床表现。患有这两种疾病的患者存在两个不同的亚组，进一步支持了 s-JIA 和 AOSD 属于同一疾病类别的观点。 (C) 2016 Elsevier Inc. 保留所有权利。
To compare pro-inflammatory cytokine profiles and kinetics inpatients with adult-onset Still's disease (AOSD) to those in patients with systemic juvenile idiopathic arthritis (s-JIA), we analyzed serum cytokine concentrations in 33 patients with AOSD and 77 patients with s-JIA and compared them with clinical features. Patients with AOSD and s-JIA shared a common cytokine profile pattern of a significant increase in IL-18. Patients with AOSD were classified into two subgroups based on serum IL-6 and IL-18 levels. The number of patients with arthritis was significantly higher in the IL-6-dominant subgroup. The cytokine patterns associated with s-JIA and AOSD share common features, such as a significant and predominant increase in IL-18. Distinct IL-6- and IL-18-based cytokine profiles might be responsible for distinct clinical manifestations. The presence of two distinct subgroups in patients with both diseases further supports the view that s-JIA and AOSD share a disease category. (C) 2016 Elsevier Inc. All rights reserved.