The Human Proteome Organization-Proteomics Standards Initiative Quality Control Working Group: Making Quality Control More Accessible for Biological Mass Spectrometry
The Human Proteome Organization-Proteomics Standards Initiative Quality Control Working Group: Making Quality Control More Accessible for Biological Mass Spectrometry
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DOI：
10.1021/acs.analchem.6b04310
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发表时间：
2017-04-18
影响因子：
7.4
通讯作者：
Tabb, David L.
中科院分区：
文献类型：
--
作者：
Bittremieux, Wout;Walzer, Mathias;Tabb, David L.
为了对生物质谱学实验的结果有信心，一个系统的质量控制方法是至关重要的。尽管如此，到目前为止，为此目的只采取了零散的举措，而且这些单独的努力往往没有相辅相成。为了解决这一问题，人类蛋白质组组织-蛋白质组学标准倡议在2016年春季的会议上设立了一个新的质量控制工作组。该工作组的目标是为质量控制数据提供一个统一的框架。最初的重点将是为质量控制提供社区驱动的标准化文件格式。为此，将对以前提议的qcML格式进行调整，以支持蛋白质组学和代谢组学应用的各种用例，并将其确立为正式的PSI格式。一个重要的考虑因素是避免执行对质量控制的限制性要求，而是提供支持任何类型的基于质谱分析的工作流程的广泛质量控制所需的基本技术必需品。我们想强调的是，这是一个开放的社区努力，我们寻求所有对这一领域感兴趣的科学家的参与。
To have confidence in results acquired during biological mass spectrometry experiments, a systematic approach to quality control is of vital importance. Nonetheless, until now, only scattered initiatives have been undertaken to this end, and these individual efforts have often not been complementary. To address this issue, the Human Proteome Organization-Proteomics Standards Initiative has established a new working group on quality control at its meeting in the spring of 2016. The goal of this working group is to provide a unifying framework for quality control data. The initial focus will be on providing a community driven standardized file format for quality control. For this purpose, the previously' proposed qcML format will be adapted to support a variety of use cases for both proteomics and metabolomics applications, and it will be established as an official PSI format. An important consideration is to avoid enforcing restrictive requirements on quality control but instead provide the basic technical necessities required to support extensive quality control for any type of mass spectrometry-based workflow. We want to emphasize that this is an open community effort, and we seek participation from all scientists with an interest in this field.