Magnetic Resonance Imaging in Multiple Sclerosis
Magnetic Resonance Imaging in Multiple Sclerosis
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DOI：
10.1101/cshperspect.a028969
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发表时间：
2018-05-01
影响因子：
5.4
通讯作者：
Bakshi, Rohit
中科院分区：
文献类型：
--
作者：
Hemond, Christopher C.;Bakshi, Rohit
自20世纪80年代初其技术发展以来，磁共振成像（MRI）已迅速成为支持多发性硬化症（MS）诊断、纵向监测、治疗反应评估和科学研究的重要工具。MRI的临床应用随着技术本身的创新而增加；临床常规MRI在1.5T的广泛采用，使得对宏观中枢神经系统（CNS）炎性脱髓鞘病变和组织萎缩进行敏感的定性和定量评估成为可能。然而，传统的MRI病变测量缺乏对MS潜在病理的特异性，与临床状态的相关性很弱。更高的场强单位和更新、先进的MRI技术在检测疾病活动和疾病严重程度方面提供了更高的灵敏度和特异性。本文综述了MRI在ms相关脑和脊髓受累表征中的作用的现状和未来前景。
Since its technical development in the early 1980s, magnetic resonance imaging (MRI) has quickly been adopted as an essential tool in supporting the diagnosis, longitudinal monitoring, evaluation of therapeutic response, and scientific investigations in multiple sclerosis (MS). The clinical usage of MRI has increased in parallel with technical innovations in the technique itself; the widespread adoption of clinically routine MRI at 1.5T has allowed sensitive qualitative and quantitative assessments of macroscopic central nervous system (CNS) inflammatory demyelinating lesions and tissue atrophy. However, conventional MRI lesion measures lack specificity for the underlying MS pathology and only weakly correlate with clinical status. Higher field strength units and newer, advanced MRI techniques offer increased sensitivity and specificity in the detection of disease activity and disease severity. This review summarizes the current status and future prospects regarding the role of MRI in the characterization of MS-related brain and spinal cord involvement.