Complement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption
Complement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption
复制标题
补体依赖性刺激前列腺素合成和骨吸收
作者：
L. Raisz;A. Sandberg;J. M. Goodson;H. Simmons;S. E. Mergenhagen
补体充足的异源血清诱导胎鼠长骨培养物中前列腺素的合成和由此产生的吸收。与加热的血清或来自缺乏补体第六成分（C6）的兔子的血清相比，未加热的正常兔血清的骨吸收增强。添加功能纯化的 C6 可恢复 C6 缺陷血清的再吸收活性。与补体充足的血清一起孵育的骨骼培养基中前列腺素 E 的浓度增加。吲哚美辛抑制活性血清的再吸收作用以及介质中前列腺素E的出现。
Complement-sufficient heterologous serum induced prostaglandin synthesis and resultant resorption in cultures of fetal rat long bones. Bone resorption was enhanced with unheated normal rabbit serum as compared to heated serum or serum from rabbits lacking the sixth component of complement (C6). Addition of functionally purified C6 restored resorptive activity in C6-deficient serum. Concentrations of prostaglandin E were increased in the culture media of bones incubated with complement-sufficient serum. The resorptive effects of active serum as well as the appearance of prostaglandin E in the media were inhibited by indomethacin.