ADAPTATION OF ADULT BRAIN-TISSUE TO ANOXIA AND HYPOXIA INVITRO
ADAPTATION OF ADULT BRAIN-TISSUE TO ANOXIA AND HYPOXIA INVITRO
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DOI：
10.1016/0006-8993(86)90418-x
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发表时间：
1986-05-28
期刊：
影响因子：
2.9
通讯作者：
RIGOR, BM
中科院分区：
文献类型：
--
作者：
SCHURR, A;REID, KH;RIGOR, BM
本研究采用大鼠海马脑片标本，观察成年大鼠脑组织对缺氧和低氧环境的适应能力。海马切片预暴露于短（5分钟）缺氧事件诱导适应。诱发的电活动的预暴露的切片恢复从随后的，更长的缺氧侮辱，而对照组（无预暴露），接受相同的侮辱，没有。适应过程是时间依赖性的;预暴露和随后的缺氧损伤之间的0.5小时的间隔允许切片抵抗13 ± 1小时的缺氧期。2分钟，而在2小时的间隔后，缺氧时间为16 ± 10分钟。2分钟可以忍受。诱发的电活动持续适应切片在暴露于缺氧，而他们的非适应控制缺氧条件下表现出突触沉默。
The rat hippocampal slice preparation was used in the present study to demonstrate the ability of adult brain tissue to adapt to anoxic and hypoxic conditions. Adaptation was induced by pre-exposure of hippocampal slices to a short (5 min) anoxic episode. The evoked electrical activity of pre-exposed slices recovered from a subsequent, longer anoxic insult, while that of controls (without pre-exposure), receiving the same insult, did not. The adaptation process is time-dependent; an interval of 0.5 h between the pre-exposure and the subsequent anoxic insult allowed slices to resist anoxic periods of 13 .+-. 2 min while after an interval of 2 h an anoxic period of 16 .+-. 2 min could be tolerated. Evoked electrical activity persisted in adapted slices during exposure to hypoxia while their non-adapted controls exhibited synaptic silence under hypoxic conditions.