HBV-DNA-RELATED HEPATOCELLULAR-CARCINOMA OCCURRING IN CHILDHOOD - REPORT OF 3 CASES
HBV-DNA-RELATED HEPATOCELLULAR-CARCINOMA OCCURRING IN CHILDHOOD - REPORT OF 3 CASES
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DOI：
10.1007/bf01297462
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发表时间：
1991-08-01
影响因子：
3.1
通讯作者：
CALLEA, F
中科院分区：
文献类型：
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作者：
GIACCHINO, R;NAVONE, C;CALLEA, F
在一系列的325 HBV慢性感染的儿童观察超过18年的时间，三个发展为肝癌。 这三个孩子出生在意大利南部，一个地区的特点是高流行性HBV感染率;每个人都被感染围产期，发展成急性肝炎，并成为慢性携带者。 三个肝硬化患者中有两个在检测到HCC时HB（s）Ag阳性。 其余病例血清转化为HB（s）Ab，但在没有肝硬化的情况下可以证明HBV-DNA整合;此外，HBV抗原在该病例的组织中不表达。 在这三个病例中，HBV感染和HCC出现之间的间隔时间为6至11年。 这三个意大利的情况下，在远东地区的慢性感染的儿童所产生的大多数肝细胞癌之间的相似性是值得注意的。
In a series of 325 HBV chronically infected children observed over an 18-year period, three developed HCC. These three children were born in southern Italy, a region characterized by a high endemic HBV infection rate; each had been infected perinatally, developed an acute hepatitis, and became a chronic carrier. Two of the three with cirrhosis were HB(s)Ag positive at the time their HCC was detected. The remaining case had seroconverted to HB(s)Ab but HBV-DNA integration could be demonstrated in the absence of cirrhosis; moreover HBV antigens were not expressed in the tissue of this case. The interval between HBV infection and HCC appearance in these three cases ranged from six to 11 years. A similarity between these three Italian cases and the majority of HCC arising in chronically infected children in the Far East is noted.