Analyzing mechanisms and microscopic reversibility of self-assembly
Analyzing mechanisms and microscopic reversibility of self-assembly
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DOI：
10.1063/1.3662140
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发表时间：
2011-12-07
影响因子：
4.4
通讯作者：
Whitelam, Stephen
中科院分区：
文献类型：
--
作者：
Grant, James;Jack, Robert L.;Whitelam, Stephen
我们使用计算机模拟来研究伴侣蛋白模型系统和伊辛晶格气体中的自组装。我们讨论了在这些系统中负责快速和有效组装的机制，并使用动态活动和组装进度的测量来比较它们的动力学捕获倾向。我们使用一个简单的最小模型的解析解来说明与这种捕获相关的关键特征，特别注意粒子可能错结合的方式的数量。我们讨论了我们的结果对一般自组装的设计和控制的相关性。(C) 2011年美国物理研究所。(doi: 10.1063/1.3662140)
We use computer simulations to investigate self-assembly in a system of model chaperonin proteins, and in an Ising lattice gas. We discuss the mechanisms responsible for rapid and efficient assembly in these systems, and we use measurements of dynamical activity and assembly progress to compare their propensities for kinetic trapping. We use the analytic solution of a simple minimal model to illustrate the key features associated with such trapping, paying particular attention to the number of ways that particles can misbind. We discuss the relevance of our results for the design and control of self-assembly in general. (C) 2011 American Institute of Physics. [doi:10.1063/1.3662140]