High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma
High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma
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自噬基因 Beclin-1 的高表达与唾液腺腺样囊性癌的良好预后相关
DOI：
10.1111/j.1600-0714.2012.01171.x
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发表时间：
2012-09-01
影响因子：
3.3
通讯作者：
Liao, Gui-Qing
中科院分区：
文献类型：
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作者：
Liang, Li-Zhong;Ma, Ben;Liao, Gui-Qing
背景：尽管自噬普遍参与肿瘤发生和肿瘤进展，但自噬和自噬调节基因在唾液腺腺样囊性癌（ACC）中的作用仍然未知。在这项研究中，我们研究了唾液腺ACC样本中自噬调节基因Beclin-1、死亡相关蛋白激酶-1、紫外线辐射抗性相关基因以及磷酸酶和张力蛋白同源物的表达。研究方法：采用免疫组化和实时荧光定量PCR技术检测89例ACC组织和正常涎腺组织中上述基因的表达。分析其表达与临床病理特征的关系。结果：与正常涎腺组织相比，这些基因在肿瘤组织中的表达明显降低。Beclin-1的表达与ACC的组织学类型有关（P < 0.05），抗紫外线相关基因的高表达与远处转移有关（P < 0.05）。结论：自噬调控基因可能参与了涎腺ACC的发病过程，对ACC自噬的研究还有待于进一步深入。
J Oral Pathol Med (2012) 41: 621629 Background: Although autophagy is universally involved in tumorigenesis and tumor progression, the roles of autophagy and autophagy-regulating genes in salivary gland adenoid cystic carcinoma (ACC) remain unknown. In this study, we investigated the expression of the autophagy-regulating genes Beclin-1, death-associated protein kinase-1, ultraviolet radiation resistanceassociated gene, and phosphatase and tensin homolog in salivary gland ACC samples. Methods: Immunohistochemistry and real-time polymerase chain reaction were used to analyze the expression of these genes in 89 ACC samples and normal salivary gland tissue samples. The relationship of their expression with clinicopathological features was analyzed. Results: The data showed significantly lower expression of these genes in the tumor samples than in normal salivary gland tissue samples. Furthermore, Beclin-1 expression was significantly correlated with histological pattern of ACC (P < 0.05), and high expression of ultraviolet radiation resistanceassociated gene was associated with distant metastasis (P < 0.05). Most importantly, univariate and multivariate survival analyses suggested that Beclin-1 protein and mRNA expression in cancer cells were independent prognostic indicators for ACC. Conclusion: Our results suggest that autophagy-regulating genes may participate in the pathogenesis of salivary gland ACC. Further research will be required to gain a better understanding of autophagy in ACC.