Valproate prevents the induction and the expression of MK-801 sensitization.
Valproate prevents the induction and the expression of MK-801 sensitization.
复制标题
丙戊酸可防止 MK-801 致敏的诱导和表达。
DOI：
10.1016/s0006-8993(02)03141-4
复制
发表时间：
2002
期刊：
影响因子：
2.9
通讯作者：
Dafny,Nachum
中科院分区：
文献类型：
--
作者：
Yang,PamelaB;Swann,AlanC;Dafny,Nachum
Repeated administration of psychostimulants such as amphetamine, cocaine, and methylphenidate has been shown to induce behavioral sensitization. Sodium valproate, an anticonvulsant agent that enhances GABA activity, and dizocilpine (MK-801), a non-competitive NMDA receptor antagonist, can block the sensitization elicited by psychostimulants. MK-801 also has been demonstrated to sensitize to itself. The objective of the present study was to determine whether valproate disrupts the behavioral sensitization elicited by MK-801. Male Sprague–Dawley rats were given a regimen of repeated MK-801 injections (0.3 mg/kg, i.p.) that produced behavioral sensitization. They were also given valproate, at a dosage (50 mg/kg, i.p.) that prevented behavioral sensitization to stimulants, either during or after multiple MK-801 injections. After the washout period, animals were then re-challenged with MK-801 to determine whether valproate disrupted the behavioral sensitization elicited by MK-801. An activity monitoring system recorded horizontal activity, total distance, and vertical activity of the animals following drug treatment. Results of their locomotor responses demonstrated that valproate disrupted the development/induction and the expression of sensitization to MK-801, as it did to methylphenidate.
