Parietal white matter abnormalities in obsessive-compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla
Parietal white matter abnormalities in obsessive-compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla
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DOI：
10.1111/j.1600-0447.2006.00858.x
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发表时间：
2006-08-01
影响因子：
6.7
通讯作者：
Someya, T.
中科院分区：
文献类型：
--
作者：
Kitamura, H.;Shioiri, T.;Someya, T.
目的：确定一个神经化学基础的假设，一个异常的皮质-皮质下回路的基础强迫症（OCD）。白色物质也被研究，因为最近的研究表明轴突的连接性改变。方法：应用3 T磁共振波谱技术，测定了12例强迫症患者前扣带回、基底节、丘脑、额、顶叶白色物质中N-乙酰天门冬氨酸（NAA）和含胆碱化合物（Cho）与肌酸/磷酸肌酸（Cr）的相对浓度，结果：脑梗死患者的Cho/Cr平均值明显高于正常对照组，但仅在顶叶白色区有显著性差异，而NAA/Cr在各脑区均无显著性差异。顶叶Cho/Cr与强迫症症状严重程度呈正相关。结论：这一发现为顶叶白色物质参与强迫症提供了间接证据，从而提示有髓轴突和/或胶质细胞磷脂的变化。
Objective: To identify a neurochemical basis for the hypothesis that an aberrant cortico-subcortical circuit underlies obsessive-compulsive disorder (OCD). The white matter was also investigated because of recent research which suggests the altered connectivity of axons.Method: Using 3-Tesla magnetic resonance spectroscopy, the relative concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) to creatine/phosphocreatine (Cr) were measured in the anterior cingulate, basal ganglia, thalamus, frontal and parietal white matter of 12 OCD patients, and 32 control subjects.Results: The mean concentration of Cho/Cr was significantly higher in the patients than in the controls, but only in the parietal white matter, while no significant group differences in NAA/Cr were observed in any of the brain regions. Parietal Cho/Cr correlated positively with the severity of OCD symptoms.Conclusion: This finding provides indirect evidence for the parietal white matter involvement in OCD, thus suggesting a change in the phospholipids of myelinated axons and/or glia cells.