A PROSPECTIVE-STUDY OF DIETARY CALCIUM AND OTHER NUTRIENTS AND THE RISK OF SYMPTOMATIC KIDNEY-STONES
A PROSPECTIVE-STUDY OF DIETARY CALCIUM AND OTHER NUTRIENTS AND THE RISK OF SYMPTOMATIC KIDNEY-STONES
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DOI：
10.1056/nejm199303253281203
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发表时间：
1993-03-25
影响因子：
158.5
通讯作者：
STAMPFER, MJ
中科院分区：
文献类型：
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作者：
CURHAN, GC;WILLETT, WC;STAMPFER, MJ
背景高钙饮食摄入量被强烈怀疑会增加肾结石的风险。然而，高钙摄入量可以减少草酸盐的尿排泄，这被认为可以降低风险。因此，较高的膳食钙摄入量增加肾结石风险的概念需要检查。我们对45，619名年龄在40至75岁之间，无肾结石病史的男性进行了一项前瞻性研究，探讨膳食钙摄入量与症状性肾结石风险之间的关系。1986年，通过半定量食物频率问卷测量了膳食钙。在4年的随访中，共记录了505例肾结石患者。经年龄校正后，膳食钙摄入量与肾结石风险呈负相关;钙摄入量最高的五分之一组男性与最低的五分之一组男性相比，肾结石的相对风险为0.56（95%置信区间为0.43至0.73;趋势P，
Background. A high dietary calcium intake is strongly suspected of increasing the risk of kidney stones. However, a high intake of calcium can reduce the urinary excretion of oxalate, which is thought to lower the risk. The concept that a higher dietary calcium intake increases the risk of kidney stones therefore requires examination.Methods. We conducted a prospective study of the relation between dietary calcium intake and the risk of symptomatic kidney stones in a cohort of 45,619 men, 40 to 75 years of age, who had no history of kidney stones. Dietary calcium was measured by means of a semiquantitative food-frequency questionnaire in 1986. During four years of follow-up, 505 cases of kidney stones were documented.Results. After adjustment for age, dietary calcium intake was inversely associated with the risk of kidney stones; the relative risk of kidney stones for men in the highest as compared with the lowest quintile group for calcium intake was 0.56 (95 percent confidence interval, 0.43 to 0.73; P for trend,