Increase in natural killer cell activity following living‐related liver transplantation
Increase in natural killer cell activity following living‐related liver transplantation
复制标题
活体相关肝移植后自然杀伤细胞活性增加
作者：
M. Hirata;Y. Kita;S. Saito;M. Nishimura;M. Ito;K. Mizuta;H. Tanaka;Y. Harihara;H. Kawarasaki;K. Hashizume;M. Makuuchi
摘要：我们监测了 8 名活体肝移植受者自然杀伤细胞 (NK) 活性的连续变化。所有八名患者的 HLA 类型与其捐赠者的单倍型相同。他克莫司和甲基强的松龙用于免疫抑制。移植前的NK活性为24.1±20.2%，与正常个体（67.7±13.2%，P < 0.01）或肝功能障碍组（49.4 ± 21.9%，P < 0.05）相比，其值低得惊人。 NK 活性的连续变化显示移植后 1 周最低为 6.1 ± 3.6%，移植后 2 个月逐渐增加至 49.2 ± 12.5%。这些结果表明患病的肝脏可能在抑制 NK 活性中发挥重要作用。
Abstract We monitored the serial changes of natural killer cell (NK) activity in eight recipients of living‐related liver transplantation. The HLA types of all eight patients were haplotypically identical with those of their donors. Tacrolimus and methylprednisolone were used for immunosuppression. The NK activity before transplantation was 24.1 ± 20.2 % which is surprisingly low when compared with the value for normal individuals (67.7 ± 13.2%, P < 0.01) or a liver dysfunction group (49.4 ± 21.9%, P < 0.05). Serial changes in NK activity revealed a minimum of 6.1 ± 3.6% 1 week after transplantation, gradually increasing to 49.2 ± 12.5 % at 2 months after transplantation. These results suggest that the diseased liver might play an important role in the suppression of NK activity.
对随机接受环孢素或 FK 506 的移植患者血液中的免疫功能和淋巴细胞表型进行连续监测。
影响因子：
0.9
作者：
Whiteside,TL;Wilson,J;Bryant,J;Zeevi,A;Abuel-Magd,K;Jain,A;Alessiani,M;Fung,J;Herberman,RB;Starzl,TE
通讯作者：
Starzl,TE