Comparison of surgical procedures for vascular and airway anastomoses that utilize a "modified" non-suture external cuff technique for experimental lung transplantation in rats
Comparison of surgical procedures for vascular and airway anastomoses that utilize a "modified" non-suture external cuff technique for experimental lung transplantation in rats
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DOI：
10.1016/j.healun.2003.06.009
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发表时间：
2004-07-01
影响因子：
8.9
通讯作者：
Wilkes, DS
中科院分区：
文献类型：
--
作者：
Mizobuchi, T;Sekine, Y;Wilkes, DS
背景：大鼠肺移植在技术上是困难的，结果可能会有所不同。非缝合袖套技术（非缝合[NS]）涉及使用袖套治疗血管和气道阻塞，通常用于执行移植手术。然而，标准支气管套囊可能堵塞管腔，导致移植物存活率降低。相比之下，无缝合套囊技术治疗血管闭塞伴支气管狭窄（支气管缝合[BS]）虽然技术难度更大，但已知可延长支气管通畅性。我们开发了一种“改良”NS技术，使用一个更大，更长的袖口为pneumoses和比较这种程序的效果BS技术肺transplantation.Methods：BS程序进行了146移植程序。改良NS手术使用比标准NS手术更大的袖带，共进行了113例手术。结果：尽管总缺血时间相当，但NS组的总手术时间明显短于BS组（p < 0.0001）。支气管瘘发生率BS组为9.6%，NS组为0%。患者两组之间的生存率相当。虽然BS技术被广泛承认，以提供长期通畅的支气管吻合，移植物的生存在NS组观察到了17个月posttransplant.Conclusions：这些数据表明，NS技术，这是技术难度较小，结果在较短的手术时间相比，BS程序，并导致持久的肺移植物。
Background: Lung transplantation in rats is technically difficult and results may vary. The non-suture cuff technique (non-suture [NS]), which involves using a cuff for anastomoses of vessels and airways, is commonly utilized to perform transplant procedures. However, the standard bronchial cuff may occlude the lumen, resulting in diminished graft survival. In contrast, the non-suture cuff technique for vascular anastomoses with bronchial suturing (bronchial suture [BS]), although more technically difficult, is known to have prolonged bronchial patency. We developed a "modified" NS technique that uses a larger and longer cuff for anastomoses and compared the efficacy of this procedure to the BS technique for lung transplantation.Methods: The BS procedure was performed in 146 transplant procedures. The modified NS procedure, which uses a larger cuff than the standard NS procedure, was performed in 113 procedures.Results: Although total ischemic times were comparable, the total operation time in the NS group was significantly shorter than in the BS group (p < 0.0001). Bronchial leakage occurred in 9.6% of BS group patients and 0% of NS group. patients. Survival rates were comparable between groups. Although the BS technique is widely acknowledged to provide prolonged patency of bronchial anastomosis, graft survival in the NS group was observed up 17 months post-transplant.Conclusions: These data show that the NS technique, which is less technically difficult, results in shorter operative times compared with the BS procedure, and results in durable anastomoses of lung grafts.