An investigation of left-right vocal fold symmetry in rheological and histological properties.
An investigation of left-right vocal fold symmetry in rheological and histological properties.
复制标题
左右声带对称性流变学和组织学特性的研究。
DOI：
10.1002/lary.27271
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Zhang,Song
中科院分区：
文献类型：
--
作者：
Xu,ChetC;Gao,Ang;Zhang,Song
目的利用兔声带模型研究声带左右对称性的流变学和组织学特性。另一个目标是建立统计模型，成对的声带之间的流变特性进行比较。MethodsViscoelastic剪切特性的6对声带固有层标本进行了测量，频率范围为1至250 Hz的线性，控制应变，简单剪切流变仪。使用混合效应模型方法对左右声带的流变学数据进行统计学比较。6个额外的兔喉进行了组织学分析左右对称的分布模式和主要的细胞外基质constituents.ResultsThere的相对密度没有显着差异的弹性剪切模量（P= 0.1069）和动态粘度（P= 0.944）的固有层之间的两个声带相同的喉。左，右声带对称的密度和分布模式的关键分子constituents.ConclusionBy显示，左，右声带流变学和组织学对称的兔，这项研究验证了一个基本的假设在许多以前的报告。还介绍了用于分析分层相关的左右声带流变学数据的统计模型。证据等级NA.喉镜，128：E359-E364，2018
ObjectivesThe primary objective was to investigate the left–right vocal fold symmetry in rheological and histological properties using a rabbit model. The other objective was to develop statistical models for the comparison of rheological properties between paired vocal folds.MethodsViscoelastic shear properties of six pairs of vocal fold lamina propria specimens were measured over a frequency range of 1 to 250 Hz by a linear, controlled‐strain, simple‐shear rheometer. The rheological data of the left and right vocal folds was statistically compared using the mixed‐effects model approach. Six additional rabbit larynges were histologically analyzed for left–right symmetry in distribution patterns and relative densities of major extracellular matrix constituents.ResultsThere were no significant differences in elastic shear modulus (P= 0.1069) and dynamic viscosity (P= 0.944) of the lamina propria between the two vocal folds of the same larynx. Left–right vocal fold symmetry in densities and distribution patterns of the key molecular constituents was also demonstrated in histological results.ConclusionBy showing that the left and right vocal folds were rheologically and histologically symmetrical in rabbit, this study validated an underlying assumption made in many previous reports. Statistical models for the analysis of hierarchically correlated left–right vocal fold rheological data were also presented.Level of EvidenceNA.Laryngoscope, 128:E359–E364, 2018