Evidence for a decrease in basilar dentrites of pyramidal cells in schizophrenic medial prefrontal cortex
Evidence for a decrease in basilar dentrites of pyramidal cells in schizophrenic medial prefrontal cortex
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DOI：
10.1016/s0920-9964(02)00201-3
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发表时间：
2002-11-01
影响因子：
4.5
通讯作者：
Jones, LB
中科院分区：
文献类型：
--
作者：
Broadbelt, K;Byne, W;Jones, LB
多种汇聚的证据线索表明前额叶皮质（PFC）与精神分裂症有关。先前的神经解剖学研究已经显示出在神经元密度、胞体大小和树突棘数量方面与精神分裂症相关的变化。我们最近证实了在内侧前额叶32区的第三层和第五层中，微管相关蛋白2（MAP2）免疫染色与精神分裂症相关的减少，并将这一发现解释为提示树突物质的缺失。我们现在展示来自11名精神分裂症患者和11名对照受试者的内侧前额叶32区的数据。在高尔基染色材料中，我们描述了第五层锥体神经元的一级（29%）和二级（46%）基底部树突数量的显著减少。同样，在第三层中，一级（17%）和二级（15%）基底部树突也有所减少。这些发现表明突触表面积减少，这可能导致异常的信息处理。（C）2002爱思唯尔科学出版社。保留所有权利。
A variety of lines of converging evidence implicates the prefrontal cortex (PFC) in schizophrenia. Previous neuroanatomical studies have shown schizophrenia-associated changes in neuron density, soma size and spine number. We recently demonstrated a schizophrenia-associated decrease in microtubule-associated protein 2 (MAP2) immunostaining in laminae III and V of medial prefrontal area 32 and interpreted that finding as suggestive of a loss of dendritic material. We now present data from medial prefrontal area 32 of II schizophrenics and II comparison subjects. In Golgi-stained material, we describe a significant decrease in the number of both primary (29%) and secondary (46%) basilar dendrites on pyramidal neurons in layer V. Similarly, in layer III there was also a decrease in both primary (17%) and secondary (15%) basilar dendrites. These findings suggest a decrease in synaptic surface area which could lead to aberrant information processing. (C) 2002 Elsevier Science B.V. All rights reserved.