Significant challenges facing HIV practitioners.

Significant challenges facing HIV practitioners.
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艾滋病毒从业者面临的重大挑战。

DOI:
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发表时间:
2008
影响因子:
6.4
通讯作者:
John Bartlett
John Bartlett
中科院分区:
医学2区
文献类型:
--
作者:
John Bartlett

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艾滋病毒感染者的护理可能已经成为医学中最有价值但也最具挑战性的专业。过去10-15年的进展是非凡的,可能是任何其他当代疾病治疗所无法比拟的。然而,与治疗相关的决定是复杂的,对错误的惩罚是严厉的。目前有24种抗逆转录病毒药物,2007年引进了两种新药。PubMed列出了去年发表的6000篇关于艾滋病治疗的文章。要跟上步伐已经变得不可能了。本《传染病杂志》增刊讨论了艾滋病毒护理的5个核心领域,这些领域具有特别具有挑战性的问题。提供了关于初始治疗、治疗失败、依从性问题、肝脏合并感染和神经系统并发症的管理的权威综述。Martin S. Hirsch b[1]回顾了关于慢性感染期间何时开始抗逆转录病毒治疗(ART)、使用药物以及是否在原发性感染期间开始治疗的最新信息
The care of patients with HIV infection has become possibly the most rewarding and yet most challenging specialty in medicine. The advances over the past 10-15 years have been extraordinary and probably are unrivaled by those for the treatment of any other contemporary disease. However, treatment-related decisions are complex, and the penalties for mistakes are harsh. There are now 24 antiretroviral drugs, with 2 new agents introduced in 2007. PubMed lists >6000 articles about HIV treatment that have been published within the past year. It is becoming impossible to keep up. This supplement to the Journal of Infectious Diseases discusses 5 areas that are central to HIV care and that are characterized by especially challenging issues. Authoritative reviews are provided regarding the management of initial therapy, failed therapy, adherence issues, hepatic coinfection, and neurological complications. Martin S. Hirsch [1] reviews the latest information about when to start antiretroviral therapy (ART) during chronic infection, as well as the drugs to use and whether to start therapy during primary
DOI: 10.1056/nejmoa062360
发表时间: 2006-11-30
影响因子: 158.5
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