Stress and the gastrointestinal tract - V. Stress and irritable bowel syndrome
Stress and the gastrointestinal tract - V. Stress and irritable bowel syndrome
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DOI：
10.1152/ajpgi.2001.280.4.g519
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发表时间：
2001-04-01
影响因子：
4.5
通讯作者：
Coutinho, SV
中科院分区：
文献类型：
--
作者：
Mayer, EA;Naliboff, BD;Coutinho, SV
不同类型的应激在肠易激综合征（IBS）症状的发生和调节中起重要作用。心理和身体应激对肠道功能和脑-肠道相互作用的生理影响是由情绪运动系统的自主神经、神经内分泌、注意力和疼痛调节反应的输出介导的。IBS患者表现出该系统的增强的反应性，表现在胃肠运动和分泌的调节改变以及内脏事件感知的改变。功能性脑成像技术开始识别与感知改变有关的脑回路。最近提出了模仿人类综合征关键特征的动物模型。
Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility and secretion and in alterations in the perception of visceral events. Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome.