Fetal renal response to atrial natriuretic factor decreases with maturation.
Fetal renal response to atrial natriuretic factor decreases with maturation.
复制标题
胎儿肾脏对心房钠尿因子的反应随着成熟而降低。
DOI：
10.1152/ajpregu.1991.260.2.r346
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Fisher,DA
中科院分区：
文献类型：
--
作者：
Castro,R;Ervin,MG;Leake,RD;Ross,MG;Sherman,DJ;Fisher,DA
妊娠早期胎儿组织和血浆中存在心房利钠因子(ANF)，提示ANF可能在子宫内的心循环稳态中起着生理作用。然而，据报道，胎儿肾脏对ANF的反应性差异很大。为了研究胎儿肾脏对ANF反应性的个体发育，对114+/-1天(n=6)和131+/-1天(n=6)的绵羊胎儿分别以5、25和100 ng·min~(-1)kg~(-1)的速率连续静脉注射ANF(各30分钟)。在较年轻和较成熟的胎儿中，平均(+/-SE)胎儿血浆ANF水平分别从328+/-54升至1,866+/-482和521+/-135升至1,579+/-295 pg/ml。平均尿量(0.17±0.03~0.37±0.09ml.min-1·kg-1)和肾小球滤过率(0.9+/-0.2~1.8+/-0.4ml.min-1·kg-1)在早孕胎儿中增加，而在大龄胎儿中无明显变化。平均尿钠排泄量和渗透压清除量在妊娠早期增加了352%和155%，在老年动物中分别增加了118%和50%。妊娠早期胎儿血浆心钠素清除率(PCANF)低于晚期胎儿(68+/-15和116+/-28mL.min-1·kg-1)。这些结果表明，随着胎龄的增加，胎儿肾脏对ANF的反应性降低。多种因素似乎起了作用，包括PCANF的变化和肾小球滤过率、肾小管功能和ANF受体代谢的成熟变化。
The presence of atrial natriuretic factor (ANF) in fetal tissues and plasma early in gestation suggests that ANF may have a physiological role in cardiocirculatory homeostasis in utero. However, reported responsiveness of the fetal kidney to ANF varies markedly. To characterize the ontogeny of fetal renal responsiveness to ANF, chronically catheterized ovine fetuses at 114 +/- 1 days (n = 6) and 131 +/- 1 days (n = 6) received successive (30 min each) intravenous infusions of ANF at rates of 5, 25, and 100 ng.min-1.kg-1. Mean (+/- SE) fetal plasma ANF levels increased from 328 +/- 54 to 1,866 +/- 482 and 521 +/- 135 to 1,579 +/- 295 pg/ml in the younger and more mature fetuses, respectively. Mean urine volume (0.17 +/- 0.03 to 0.37 +/- 0.09 ml.min-1.kg-1) and GFR (0.9 +/- 0.2 to 1.8 +/- 0.4 ml.min-1.kg-1) increased in the early gestation fetuses but did not change in the older fetuses. Mean urine sodium excretion and osmolar clearance increased by 352 and 155% in the early gestation fetal lambs and 118 and 50% in the older animals. The fetal plasma ANF clearance rates (PCANF) were lower in the early vs. the late gestation fetuses (68 +/- 15 vs. 116 +/- 28 ml.min-1.kg-1, respectively). These results demonstrate a decrease in fetal renal responsiveness to ANF with advancing fetal age. Multiple factors appear to contribute, including changes in PCANF and maturational changes in glomerular filtration rate, renal tubular function and ANF receptor metabolism.