REGULATION OF MALE-RAT COPULATORY-BEHAVIOR BY PREOPTIC INCERTOHYPOTHALAMIC DOPAMINE NEURONS
REGULATION OF MALE-RAT COPULATORY-BEHAVIOR BY PREOPTIC INCERTOHYPOTHALAMIC DOPAMINE NEURONS
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DOI：
10.1016/0361-9230(88)90062-7
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发表时间：
1988-03-01
影响因子：
3.8
通讯作者：
LOOKINGLAND, KJ
中科院分区：
文献类型：
--
作者：
BITRAN, D;HULL, EM;LOOKINGLAND, KJ
研究了大鼠内侧视前区（MPO）多巴胺能末端在雄性大鼠交配行为调控中的作用。将6-羟多巴胺（6-OHDA）注射到去西帕明预处理动物的MPO中，会导致DA的少量（23%）消耗，而不会损害交配活性。用α -甲基对酪氨酸（AMPT）进一步消耗儿茶酚胺会导致6-oHDA处理的雄性交配行为出现一些缺陷，而在6-oHDA处理之前，AMPT的剂量并未对交配产生不利影响。6-羟多巴胺注入MPO后，APO颅内注射的剂量相关效应也发生改变。先前发现的抑制作用为0.2 .mu。正常男性侧脑室的APO被6-OHDA所消除。注射0.2 μ后，观察到交配行为的促进。6-羟多巴胺处理动物的MPO，而这种处理不影响正常动物的交配行为。最后，注射0.1 .mu后观察到抑制作用。正常男性APO向MPO的转运被6-OHDA阻断。讨论了突触前自受体和突触后DA受体在MPO中介导APO对交配行为的剂量相关效应中的相对作用。
The role of dopaminergic terminals in the medial preoptic area (MPO) in the regulation of male rat copulatory behavior was investigated. A 6-hydroxydopamine (6-OHDA) injection into the MPO of animals pretreated with desipramine resulted in a small (23%) depletion of DA, and no impairment of copulatory activity. Further depletion of catecholamines with alpha-methyl p-tyrosine (AMPT) produced several deficits in the copulatory behavior of 6-OHDA-treated males, at a dose of AMPT that did not adversely effect copulation prior to 6-oHDA administration. The dose-related effects of intracranial apomorphine (APO) injections were also altered by 6-OHDA injections into the MPO. The inhibition previously found with 0.2 .mu.g of APO into the lateral ventricle of normal males was abolished by 6-OHDA treatment. A facilitation of copulatory behavior was observed following the injection of 0.2 .mu.g of APO into the MPO of 6-OHDA-treated animals, whereas this treatment did not affect the copulatory behavior of intact animals. Finally, inhibitory effects observed following an injection of 0.1 .mu.g of APO into the MPO of normal males were blocked by 6-OHDA administration. The relative roles of presynaptic autoreceptors and postsynaptic DA receptors in the MPO in mediating the dose-related effects of APO on copulatory behavior are discussed.