Epstein-Barr virus-positive inflammatory pseudotumour and inflammatory pseudotumour-like follicular dendritic cell tumour
Epstein-Barr virus-positive inflammatory pseudotumour and inflammatory pseudotumour-like follicular dendritic cell tumour
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DOI：
10.1259/bjr/66918927
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发表时间：
2009-04-01
影响因子：
2.6
通讯作者：
Ohtomo, K.
中科院分区：
文献类型：
--
作者：
Kiryu, S.;Takeuchi, K.;Ohtomo, K.
据报道，各种脾脏炎性假瘤感染了EB病毒（EBV），这被认为是与病变的发病机制。术语“炎性假瘤（IPT）样滤泡树突状细胞肿瘤”，其中所有的情况下，也是EBV阳性，最近已提出。在这里，我们描述了这些脾脏肿瘤的影像学表现，并提出了一个IPT样滤泡树突状细胞肿瘤和两个EBV阳性炎性假瘤的情况下，在两名女性患者和一名男性患者。这些脾脏病变是在术前或术后筛查或体检时偶然发现的。三位病人的电脑断层都显示脾脏内有低密度的孤立性肿块。1例患者行MRI检查，孤立性肿块在T1加权像上呈等信号，在T2加权像上呈低信号。动态MRI检查显示肿块早期不强化，延迟期强化程度与周围脾实质一致。影像学检查结果与传统IPT几乎相同，因为两种情况下的形态学相似;然而，由于其肿瘤性质，在诊断脾脏病变时应注意这种新实体。与传统IPT相比，这些患者还需要更长的随访时间。
Various splenic inflammatory pseudotumours are reported to be infected with Epstein-Barr virus (EBV), which is thought to be associated with the pathogenesis of the lesion. The term "inflammatory pseudotumour (IPT)-like follicular dendritic cell tumour", all cases of which are also EBV positive, has recently been proposed. Here, we describe the imaging findings of these splenic tumours and present the cases of an IPT-like follicular dendritic cell tumour and two EBV-positive inflammatory pseudotumours in two female patients and one male patient. These splenic lesions were found incidentally on pre-operative or post-operative screening or at medical check-up. CT performed on all three patients revealed low-density solitary masses in the spleen. MRI was performed on one patient; the solitary mass demonstrated isointensity on T(1) weighted images and low intensity on T(2) weighted images relative to the surrounding splenic parenchyma. Dynamic MRI study revealed that the mass did not enhance on the early phase but enhanced to the same degree as the surrounding splenic parenchyma on the delayed phase. The imaging findings are almost identical to those found in conventional IPT because the morphology is similar in both cases; however, attention should be paid to this new entity in the diagnosis of splenic lesions because of its neoplastic nature. Longer follow-up is also necessary for these patients compared with those with conventional IPT.