Nickel-Catalyzed Cross-Coupling of Bromodifluoromethylphosphonates with Arylboron Reagents
Nickel-Catalyzed Cross-Coupling of Bromodifluoromethylphosphonates with Arylboron Reagents
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DOI：
10.1002/adsc.202201140
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发表时间：
2023-01-11
影响因子：
5.4
通讯作者：
Onomura，Osamu
中科院分区：
文献类型：
--
作者：
Kuriyama，Masami;Maeda，Genki;Onomura，Osamu
溴二氟甲基膦酸酯与芳基硼试剂的镍催化交叉偶联是用1，10-菲咯啉型配体开发的。在这个过程中，功能化的和含杂环的环硼氧烷被发现是合适的合作伙伴，和生物活性分子的催化修饰，如非诺贝特和吲哚美辛，也成功地实现。此外，克级反应顺利进行，以高产率得到所需产物。
The nickel‐catalyzed cross‐coupling of bromodifluoromethylphosphonates with arylboron reagents was developed with a 1,10‐phenanthroline‐type ligand. In this process, functionalized and heterocycle‐containing boroxines were found to be suitable partners, and the catalytic modification of biologically active molecules, such as fenofibrate and indomethacin, was also successfully achieved. Furthermore, the gram‐scale reaction smoothly proceeded to give the desired product in a high yield.