Cortical activity in multiple motor areas during sequential finger movements: An application of independent component analysis
Cortical activity in multiple motor areas during sequential finger movements: An application of independent component analysis
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DOI：
10.1016/j.neuroimage.2005.06.022
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发表时间：
2005-11-15
期刊：
影响因子：
5.7
通讯作者：
Kitazawa, S
中科院分区：
文献类型：
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作者：
Kansaku, K;Muraki, S;Kitazawa, S
多个皮质区域，如辅助运动区(SMA)、运动前皮质(PM)和初级运动皮质(M1)参与了手部动作的顺序执行，但这些区域如何在同侧和对侧手部动作的准备和执行中协作尚不清楚。在这项研究中，我们使用右撇子受试者，通过对事件相关功能磁共振成像(FMRI)信号的独立成分分析(ICA)，研究了视觉线索连续手指运动过程中运动相关活动的空间分布和时间分布。ICA方法的独特优点是，它允许阐明单个受试者的大脑活动，而不需要对激活的解剖区域或活动的时间分布做出先验假设。通过应用ICA，我们发现：(1)SMA参与了右手和左手运动的准备和执行；(2)左侧M1和背侧运动前皮质(PMD)参与了右手和左手运动的准备和执行，而右侧M1和PMD主要参与了左手运动的准备和执行；(3)在一些受试者中，SMA前区域与后顶叶和前额叶皮质一起激活；(4)皮质浅引流静脉上的fMRI信号可以被区分为前皮质激活。我们认为，ICA有助于将个体中的分布式任务相关活动分类为几个空间独立的活动，这些活动代表运动控制中的功能单位。(C)2005 Elsevier Inc.保留所有权利。
Multiple cortical regions such as the supplementary motor area (SMA), premotor cortex (PM), and primary motor cortex (M1) are involved in the sequential execution of hand movements, but it is unclear how these areas collaborate in the preparation and execution of ipsilateral and contralateral hand movements. In this study, we used right-handed subjects to examine the spatial distribution and temporal profiles of motor-related activity during visually cued sequential finger movements by applying independent component analysis (ICA) to event-related functional magnetic resonance imaging (fMRI) signals. The particular merit of the ICA method is that it allows brain activity in individual subjects to be elucidated without making a priori assumptions about the anatomical areas that are activated or the temporal profile of activity. By applying ICA, we found that (1) the SMA contributed to both the preparation and execution of movements of the right and left hand; (2) the left M1 and dorsal premotor cortex (PMd) contributed to both the preparation and execution of movements of the right and left hand, whereas the right M1 and PMd contributed mainly to the execution of movements of the left hand; (3) pre-SMA areas were activated in some subjects in concert with the posterior parietal and prefrontal cortex; and (4) fMRI signals over superficial cortical draining veins could be distinguished front cortical activation. We suggest that ICA is useful for categorizing distributed task-related activities in individual subjects into several spatially independent activities that represent functional units in motor control. (c) 2005 Elsevier Inc. All rights reserved.