Correlation of the physical and genetic maps in the lin-12 region of Caenorhabditis elegans.
Correlation of the physical and genetic maps in the lin-12 region of Caenorhabditis elegans.
复制标题
秀丽隐杆线虫 lin-12 区域物理图谱和遗传图谱的相关性。
DOI：
10.1093/nar/15.5.2295
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发表时间：
1987
影响因子：
14.9
通讯作者：
Priess,J
中科院分区：
文献类型：
--
作者：
Greenwald,I;Coulson,A;Sulston,J;Priess,J
我们描述了LIN-12 III染色体区长约600kb的一组重叠克隆的组装，以及两个限制性片段长度多态EP6和EP7的鉴定。在林-12轨道的侧翼。物理图谱和遗传图谱的比较得出了eP6lin-12区间的930kb/map单位和lin12eP7区间的830kb/map单位的近似测量值。我们将这些值解释为支持这一观点，即在常染色体上观察到的基因的明显聚集性是由于簇内生态结合频率的降低而不是由于基因在物理图谱上的非随机分布。
We describe the assembly of a set of overlapping clones from the lin-12 III chromosomal region that spans approximately 600 kb, and the identification of two restriction fragment length polymorphisms, eP6 and eP7. that flank the lin-12 locus. A comparison of the physical map and the genetic map yields approximate measurements of 93 0 kb/map unit for the eP6lin-12 interval and 830 kb/map unit for the lin12eP7 interval. We interpret these values as supporting the proposal that the apparent clustering of genes observed for C. eleaans autosomes results from decreased ecombination frequency in clusters and not from nonrandom distribution of genes on the physical map.